Correlation between cardiac troponin I levels and area of myocardial vascular necrosis in the patients with fatal outcome


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Abstract

Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The purpose of this study was to assess the possibility of using a high-sensitive method for cardiac troponin I test for risk stratification of the patients with myocardial infarction and for clinico-morphological prediction of the development of the disease. Materials and methods. The study was conducted on the basis of cardiac surgery center and city patho-anatomical bureau. 89 patients with a fatal outcome were admitted to the hospital with a diagnosis of acute coronary syndrome during 2016 year. The level of cardiac troponin I was tested by high-sensitive chemiluminescent method on microparticles. Histological staining was by hematoxylin and eosin, by the method of Regaud, Lie, selectively performed the PAS reaction. Results. At the analysis of the correlation between cardiac troponin I concentration and size of myocardial infarcted area, the Spearman correlation coefficient was 0,57 (p<0.001), which according to the Chaddock scale corresponds to a moderate positive correlation. Patients with ECG ST segment elevation had statistically significantly higher concentrations of the cardiac marker and infarct sizes, the values of the Mann-Whitney U test are equal to U=140 atp<0.02 and U=117 atp<0.04, respectively. Conclusion. The results of the study showed the possibility of using a high sensitive troponin I as a reliable tool for establishing the correlation of cardiac troponin I levels by a highly sensitive method with the extent of damage to the cardiac muscle in patients with acute coronary syndrome and its effective use as a risk stratification in complex schemes.

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About the authors

A. S Pushkin

I.P. Pavlov First Saint Petersburg State Medical University; St.-Petersburg Municipal Clinical Hospital №2

Email: pushkindoc@mail.ru

I. A Danilova

St.-Petersburg Municipal Pathoanatomical Bureau

V. A Volchkov

St. Petersburg State University; St.-Petersburg Municipal Clinical Hospital №2

A. A Yakovlev

St. Petersburg State University; St.-Petersburg Municipal Clinical Hospital №2

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