Effect of regular aerobic physical load on the morphometric indicators of the visceral and subcutanial fat tissue of rats


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Abstract

Introduction. Excess and lack of adipose tissue are associated with a violation of its functions, the mass of adipose tissue and its distribution play an important role in the development of metabolic disorders. The study of the influence of the main factors of influence on adipose tissue - nutrition and physical activity are topical issues. The aim of the study. To assess the effect of aerobic exercise on the morphometric parameters of white adipose tissue of rats on the background of increased caloric intake (with a predominance of vegetable and animal fat in the diet). Methods. The experimentations were carried out on 64 male Wistar rats. Rats’ body mass, body length, body mass index, lean mass, specific weight of adipose tissue were estimated, adipocyte size. Results. Aerobic physical activity provided with high-calorie diet resulted in decrease of body mass, body mass index, lean mass and adipose tissue density. Abovementioned parameters changed proportionally in the group of animals with animal fat prevalence in nutrition, whereas more expressed decrease of adipose tissue mass due to subcutaneous fat was discovered in the group of animals with vegetable fat prevalence in nutrition. Reduction of adipocytes average size was observed with same prevalence in all adipose depots provided with animal fat prevalence nutrition. Reduction of average size of adipocytes of retroperitoneal and mesenteric adipose depots, provided with vegetable fat prevalence nutrition. Conclusion. Physical activity greatly influenced adipose tissue mass, qualitative and quantitative changes of average size of adipocytes in adipose depots are more effective provided with high vegetable fat content nutrition.

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About the authors

I. Yu Yakimovich

Siberian State Medical University

S. V Gusakova

Siberian State Medical University

M. Yu Kotlovsky

Siberian State Medical University

V. V Ivanov

Siberian State Medical University

V. N Vasilyev

Siberian State Medical University

A. M Dygai

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Yu. G Samoylova

D. A Kudlay

State Research Center «Institute of Immunology» of the Federal Medical-Biological Agency

References

  1. Филатова Г.А., Дэпюи ТИ., Гришина ТИ. Ожирение: спорные вопросы, определяющие метаболическое здоровье. Эндокринология: новости, мнения, обучение. 2018; 7 (1): 58-67
  2. Goossens G.H. The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function. Obes Facts. 2017; 10 (3): 207-15.
  3. Мяделец О. Д., Мяделец В. О., Соболевская И. С., Кичигина Т Н. Белая и бурая жировые ткани: взаимодействие со скелетной мышечной тканью. Вестник ВГМУ 2014; 13 (5): 32-44.
  4. Бородкина Д.А., Груздева О.В., Квиткова Л.В., Барбараш О.Л. Распределение жировых отложений: разгадка кажущегося парадокса ожирения в кардиологии? Ожирение и метаболизм. 2017; 14 (2): 3-8.
  5. Lee M.J., Wu Y, Fried S.K. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol. Aspects Med. 2013; 34 (1): 1-11.
  6. Никоноров А. А., Тиньков А. А., Железнов Л. М., Иванов В. В. Методический подход к изучению ожирения в эксперименте. Оренбург: ОАО «ИПК «Южный Урал»; 2013; 240.
  7. Бородкина Д.А., Груздева О.В., Квиткова Л.В., Барбараш О.Л. Можно ли назвать висцеральное ожирение ключевым фактором парадокса ожирения? Проблемы эндокринологии. 2016; 6: 33-9
  8. Самойлова Ю.Г, Ротканк М.А., Жукова Н.Г, Матвеева М.В., Толмачев И.В., Кудлай Д.А. Вариабельность гликемии у пациентов с сахарным диабетом 1-го типа: связь с когнитивной дисфункцией и данными магнитнорезонансных методов исследования. Проблемы Эндокринологии. 2018; 64 (5): 286-91
  9. Самойлова Ю.Г., Ротканк М.А., Жукова Н.Г. и др. Применение магнитно-резонансных методов исследования головного мозга у пациентов с сахарным диабетом 1-го типа и когнитивной дисфункцией. Неврол. журн. 2018; 23 (2): 86-92
  10. Soderlund A., Fischer A., Johansson T. Physical activity, diet and behaviour modification in the treatment of overweight and obese adults: a systematic review. Perspect Public Health. 2009; 129: 1132-42
  11. Wu T., Gao X., Chen M., van Dam R. M. Longterm effectiveness rof diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis. Obes. Rev. 2009;10: 313-23
  12. Araujo G.G., Araujo M.B., D'Angelo R.A. et al. Maximal lactate steady state in obese rats of both gender. Brasilian J. of Sports Medicine. 2009; 15 (1): 46-9
  13. Криволапов Ю.А., Леенман Е.Е. Морфологическая диагностика лимфом. СПб.: Издательско-полиграфическая компания «КОСТА», 2006; 208
  14. Sebastian D.P., Stephen I.L., Hiroyuki M. et al. Quantifying Size and Number of Adipocytes in Adipose Tissue. Methods Enzymol. 2014; 537: 93-122
  15. Vegiopoulos A., Rohm M., Herzig S. Adipose tissue: between the extremes. EMBO J. 2017; 36 (14): 1999-2017
  16. Мамаев А.Н., Кудлай Д.А. Визуализация данных в презентациях, отчетах и исследованиях. М.: Практическая медицина, 2011; 39
  17. Абдурашитова Ш.А. Роль рационального питания в профилактике сердечно-сосудистых заболеваний. Молодой ученый. 2017; 20: 177-9. https://moluch.ru/archive/154/42764
  18. ACSM. American College of Sports Medicine. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exercise. 2009. https://doi.org/10.1249/MSS.0b01381949333
  19. McQuaid S.E., Hodson L., Neville M.J., Dennis A.L., Cheeseman J., Humphreys S.M., Ruge T, Gilbert M., Fielding B.A., Frayn K.N., Karpe F. Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes. 2011; 60: 47-55.
  20. Hannukainen J.C., Kalliokoski K.K., Borra R.J., Viljanen A.P., Janatuinen T., Kujala U.M., Kaprio J., Heinonen O.J., Viljanen T, Haaparanta M., Iozzo P., Parkkola R., Nuutila P. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity. 2010; 18: 261-5.
  21. Hoffstedt J., Arner E., Wahrenberg H., Andersson D.P., Qvisth V., Lofgren P., Ryden M., Thorne A., Wiren M., Palmer M., Thorell A., Toft E., Arner P. Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia. 2010; 53: 2496-503.
  22. Ibrahim M.M. Subcutaneous and visceral adipose tissue: structural and functional differences. Obesity Reviews. 2009; 11: 11-8.
  23. Varlamov O., Somwar R., Cornea A., Kievit P., Grove KL., Roberts CT Jr.Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. Am. J. Physiol. Endocrinol. Metab. 2010; 299: 486-96.

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