Neuroimmunoendocrine profile of sarcoid granulema: expression of signal molecules
- Authors: Yablonsky P.K1, Polyakova V.O1,2, Krylova Y.S1,3, Drobintseva A.O1,4, Leonteva D.O1, Sokolovich E.G1, Kvetnoy I.M1,2
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Affiliations:
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- Saint-Petersburg University
- Pavlov First Saint Petersburg State Medical University
- St. Petersburg State Pediatric Medical University
- Issue: Vol 18, No 1 (2020)
- Pages: 16-20
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113203
- DOI: https://doi.org/10.29296/24999490-2020-01-03
- ID: 113203
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Abstract
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown etiology, which leads to disruption of the human respiratory system and can lead to damage to other systems. In clinical practice, doctors often run into difficulties in differentiating sarcoidosis from tuberculosis - another granulomatous disease, because of their similar clinical and radiological pictures. None of the existing methods for diagnosing sarcoidosis or tuberculosis is absolute. However, the correct and timely diagnosis plays an important role in the successful treatment of these pulmonary pathologies. The aim of the study. Determination of the neuro-immuno-endocrine profile of sarcoid granuloma. Methods. Namely, proteins were studied: interleukin-8 (IL8), Protein gene product 9.5 (PGP9.5), tissue inhibitor of metalloproteinases (TIMP1), melatonin receptor 1A (RM-1A), melatonin receptor 1B (RM-1B). Results. Studies have shown sarcoid granulomas to express IL-8 with the presence of nerve - PGP9.5 positive terminals in peri-granuloma tissue, thus labeling granuloma, we suggest IL-8 be able to become a diagnostic marker of lung sarcoidosis. The data on the expression of TIMP1, RM-1A, and RM-2B are ambiguous and require further study. Conclusion. Thus, the neuro-immuno-endocrine aspects of granulomatous inflammation are interesting for further research at various stages of sarcoidosis, as well as for tuberculosis.
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About the authors
P. K Yablonsky
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
V. O Polyakova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg University
Yu. S Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Pavlov First Saint Petersburg State Medical University
A. O Drobintseva
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; St. Petersburg State Pediatric Medical University
D. O Leonteva
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
E. G Sokolovich
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
I. M Kvetnoy
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg University
Email: igor.kvetnoy@yandex.ru
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