PROTECTIVE IMPACT OF BIOREGULATOR PEPTIDES BY EFFECT OF CONSTANT GEOMAGNETIC FIELD ON ORGANOTYPIC TISSUE CULTURE OF VARIOUS GENESIS
- Authors: Chalisova N.I1,2, Rubinskii A.V3, Vlasov T.D3
-
Affiliations:
- Pavlov Institute of Physiology
- St. Petersburg Institute of Bioregulation and Gerontology
- Pavlov First State Medical Institute
- Issue: Vol 18, No 2 (2020)
- Pages: 51-53
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113247
- DOI: https://doi.org/10.29296/24999490-2020-02-09
- ID: 113247
Cite item
Open Access
Access granted
Abstract
Introduction. The investigations of the magnetic-biological effects are actual because the modern technical works are related to the constant magnetic field (CGF) Purpose of the study was the investigation of impact of (CMF) on the tissues of various genesis - ecto-, meso- and entodermal. Method of organotypic culture of tissues of Wistar line rats was used. Results. CMF with 200 mTl induction had no effect on the tissues of meso- and entodermal genesis (liver, kidney, prostate gland, myocardium). However CMF inhibited CMF cell proliferation in the nervous tissue of brain cortex and in the spleen immune tissue. The introduction in the cultural media of bioregulator peptides MNN-1 and MNN-2 delated the inhibitory CMF effect and the cell proliferation was as in the control explants. Conclusion. The data obtained the protective effect of bioregulator can be used for the normalization of the proliferation potential of tissues, and also for the elaboration of the scientific recommendations for the reglament norms by exploitation of magnetic-levitation transport systems and for the passenger and workers protection from the technogenic effect
Full Text
About the authors
N. I Chalisova
Pavlov Institute of Physiology; St. Petersburg Institute of Bioregulation and Gerontology
Email: ni_chalisova@mail.ru
St. Petersburg, Russian Federation
A. V Rubinskii
Pavlov First State Medical InstituteSt. Petersburg, Russian Federation
T. D Vlasov
Pavlov First State Medical InstituteSt. Petersburg, Russian Federation
References
- Jandova A., Mhamdi L, Nedbalova M. et al. Electromagnetic Biology and Medicine. 2005; 24 (3): 283-92.
- Бучаченко А.Л. Магнито-зависимые молекулярные и химические процессы в биохимии, генетике и медицине. Успехи химии. 2014; 83 (1): 1-12.
- Miyakoshi J. Effects of static magnetic fields at the cellular level. Progress in Biophysics and Molecular Biology. 2005; 87 (2): 213-23.
- Чалисова Н.И., Концевая Е.А., Войцеховская М.А., Рыжак.А. Влияние коротких пептидов на развитие органотипической культуры ткани кожи молодых и старых крыс. Профилактическая и клиническая медицина. 2011; 2 (2): 110-3.
- Чалисова Н.И., Вахитов Т.Э., Полевая Е.В., Козина Л.С., Концевая Е.А., Салль Т.С., Заломаева Е.С. Влияние генетически кодируемых аминокислот и их предшественников карбоновых кислот на клеточную пролиферацию в органотипической культуре селезенки у молодых и старых крыс. Успехи геронтологии. 2017; 30 (1): 39-42.
- Хавинсон В.Х., Кузник Б.И., Рыжак Г.А. Пептидные биорегуляторы - новый класс геропротекторов. Успехи геронтологии. 2013; 26 (1): 20-37.
- Khavinson V, Micans P., Maryanovich A. Peptides in the Epigenetic Control of Ageing. Great Britain: Profound Health Ltd. 2017; 116.
- Заморский И.И., Щудрова Т.С., Зеленюк В.Г, Линькова Н.С., Ничик Т.Е., Хавинсон В.Х. Влияние пептидов на морфофункциональное состояние почек у старых крыс. Успехи геронтол. 2018; 31 (4): 498-504.
- Otmishi P., Gordon J., El-Oshar S., Li H, Guardiola J, Saad M, Proctor M, Yu J. Neuroimmune interaction in inflammatory diseases. Clin. Med. Circ. Respirat. Pulm. Med. 2008; 29 (2): 35-44.
Supplementary files
