Stimulating effect of tetrapeptide AEDG on morphologic and functional characteristics of the nervous tissue
- Authors: Chalisova N.I1, Lopatina N.G1, Kamishev N.G1, Zachepilo T.G1
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Affiliations:
- Pavlov Institute of Physiology RAS
- Issue: Vol 18, No 4 (2020)
- Pages: 47-49
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113295
- DOI: https://doi.org/10.29296/24999490-2020-04-07
- ID: 113295
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Abstract
Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG effect on the nervous tissue of various organism species. Methods of organotypic culture of brain nervous tissue of Wistar line rats and conditioning of proboscis extension in honeybees Apis mellifera were used. Results. AEDG effect at 10~s Мconcentration stimulates the cell proliferation in the rat brain nervous tissue, and at 10-5 Мconcentration stimulates the condition reflex preservation both in the honeybee short- and long term memory. Conclusion. The data about tetrapeptide AEDG stimulating effect on the cellular proliferation in the rat brain nervous tissue and on the function of the honeybee central nervous system can be used for creating preparations for treatment of this pathology of the nervous tissue. The parallelism of AEDG effect in two animal species resolves to suggest about the unique evolutionary mechanism of the peptide regulation in the living organism.
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About the authors
N. I Chalisova
Pavlov Institute of Physiology RAS
Email: ni_chalisova@mail.ru
N. G Lopatina
Pavlov Institute of Physiology RAS
N. G Kamishev
Pavlov Institute of Physiology RAS
T. G Zachepilo
Pavlov Institute of Physiology RAS
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