Stimulating effect of tetrapeptide AEDG on morphologic and functional characteristics of the nervous tissue


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Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG effect on the nervous tissue of various organism species. Methods of organotypic culture of brain nervous tissue of Wistar line rats and conditioning of proboscis extension in honeybees Apis mellifera were used. Results. AEDG effect at 10~s Мconcentration stimulates the cell proliferation in the rat brain nervous tissue, and at 10-5 Мconcentration stimulates the condition reflex preservation both in the honeybee short- and long term memory. Conclusion. The data about tetrapeptide AEDG stimulating effect on the cellular proliferation in the rat brain nervous tissue and on the function of the honeybee central nervous system can be used for creating preparations for treatment of this pathology of the nervous tissue. The parallelism of AEDG effect in two animal species resolves to suggest about the unique evolutionary mechanism of the peptide regulation in the living organism.

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作者简介

N. Chalisova

Pavlov Institute of Physiology RAS

Email: ni_chalisova@mail.ru

N. Lopatina

Pavlov Institute of Physiology RAS

N. Kamishev

Pavlov Institute of Physiology RAS

T. Zachepilo

Pavlov Institute of Physiology RAS

参考

  1. Хавинсон В.Х., Кузник Б.И., Рыжак ГА. Пептидные биорегуляторы - новый класс 4. геропротекторов. Успехи геронтологии. 2013; 26 (1): 20-37
  2. Vanyushin B.F., Khavinson V.Kh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. Epigenetics -A Different Way of Looking at Genetics. W Doerfler, P Bohm (eds.). - Springer International Publishing Switzerland. 2016; 69-90
  3. Чалисова Н.И., Концевая Е.А., Войцеховская М.А., Рыжак ГА. Влияние коротких пептидов на развитие органотипической культуры ткани кожи молодых и старых крыс. Профилактическая и клиническая медицина. 2011; 2 (2): 110-3
  4. Чалисова Н.И., Жекалов А.Н. Влияние дипептида лейцинлизин на развитие культуры ткани миокарда и селезенки. Успехи геронтологии, 2014; 27 (3): 41-5
  5. Asok A., Leroy F., Rayman J.B., Kandel E.R. Molecular Mechanisms of the Memory Trace. Trends Neurosci. 2019; 42 (1): 14-22. https://doi.org/10.1016Zj.tins.2018.10.005.
  6. Menzel R. The insect mushroom body, an experience-dependent recording device. J. Physiol Paris. 2014; 108 (2-3): 84-95. https:// doi.org/10.1016/j.jphysparis.2014.07.004.
  7. Bitterman M.E., Menzel R., Fietz A., Schafer S. Classical conditioning of proboscis extension in honeybees (Apismellifera). J. Comp Psychol. 1983; 97 (2): 107-19.
  8. Лопатина Н.Г, Рыжова И.В., Чеснокова Е.Г, Дмитриева Л.А. Рецепторы L-глутамата в центральной нервной системе медоносной пчелы Apis mellifera и их роль в процессе формирования условного рефлекса и следов памяти. Журнал эволюционной биохимии и физиологии. 1997; 33 (6): 506-12.
  9. Хавинсон В.Х., Лопатина Н.Г, Чалисова Н.И., Зачепило Т.Г, Линькова Н.С., Халимов РИ., Камышев Н.Г. Трипептид модулирует условно-рефлекторную деятельность медоносной пчелы Apis mellifera L. Фундаментальные исследования. 2015; 2: 491-6
  10. Khavinson V, Micans P, Maryanovich A. Peptides in the Epigenetic Control of Ageing. Great Britain: Profound Health Ltd. 2017; 116

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