Protective effect of bioregulatory peptides on the organotypic tissue culture development in cytostatic presence


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of healthy cells. Aim of the study. To investigate bioregulatory peptide effects on a decrease of cytostatic inhibition in the culture of different genesis Methods. Organotypic culturing of tissue of the brain cortex, spleen, kidney of Wistar line rats under the presence of cytostatic cyclophosphane (CP) as well the complex and synthesized peptides also were used. Results. The combined effect of complex peptide thymalin or the synthesized peptide KE cytostatic inhibiting effect on the cellular proliferation in the tissues of different genesis is decreased by 14-28%. Conclusion. The obtained data about the effect of bioregulatory peptides create the base for their further investigation as the drugs for the delay of adverse effects by the cytostatic therapy. These drugs can be used in clinical practice for the treatment of cancer patients, receiving cytostatic therapy.

全文:

受限制的访问

作者简介

G. Rizhak

St.Petersburg Institute of Bioregulation and Gerontology

Email: galina@gerontology.ru
Director Assistance of Petersburg Institute of Bioregulation and Gerontology. Petersburg Institute of Bioregulation and Gerontology Russian Federation, Doctor of medical sciences, Professor Dinamo pr., 3, St. Petersburg, 197110, Russian Federation

N. Chalisova

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Email: ni_chalisova@mail.ru
Expert scientific worker Pavlov Institute of Physiology RAS, Doctor of biologic sciences, Professor Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

O. Ivko

St.Petersburg Institute of Bioregulation and Gerontology

Email: secretary@gerontology.ru
Senior scientific worker of St.Petersburg Institute of Bioregulation and Gerontology, Candidate of biologic sciences Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

E. Zalomaeva

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Email: zalomaeva.e@yandex.ru
postgraduate of. Pavlov Institute of Physiology RAS Dinamo pr., 3, St. Petersburg, 197110, Russian Federation

P. Ivanova

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Laboratory worker of Pavlov Institute of Physiology Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

参考

  1. Лебединская Е.А., Лебединская О.В., Годовалов А.П., Прокудин В.С. Иммуноморфологические особенности тимуса крыс на фоне введения цитостатика в эксперименте. Саратовский научно-медицинский журнал. 2016; 12 (1): 12-4
  2. Emadi A., Jones R. J., Brodsky R. A. Cyclophosphamide and cancer: golden anniversary Nat. Rev. Clin. Oncol. 2009; 1: 146-9. https://doi.org/10.1038/nrclinonc.
  3. Khavinson V, Popovich I. Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span. RSC Drug Discovery Series №57 «Anti-aging Drugs: From Basic Research to Clinical Practice». Ed. A.M. Vaiserman. 2017: 496-513.
  4. Хавинсон В.Х., Кузник Б.И., Рыжак Г.А. Пептидные биорегуляторы - новый класс геропротекторов. Успехи геронтологии. 2013; 26 (1) 20-37.
  5. Vanyushin B.F., Khavinson V.Kh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. Epigenetics -A Different Way of Looking at Genetics. W. Doerfler, P Bohm (eds.). - Springer International Publishing Switzerland. 2016: 69-90.
  6. Чалисова Н.И., Жекалов А.Н. Влияние дипептида лейцинлизин на развитие культуры ткани миокарда и селезенки. Успехи геронтологии, 2014; 27 (3): 41-5.
  7. Рыжак А.П., Чалисова Н.И., Линькова Н.С. Влияние полипептидов на регенерацию клеток в культуре разных тканей молодых и старых крыс. Успехи геронтологии. 2015; 28 (1): 97-103
  8. Заморский И. И., Щудрова Т С., Зеленюк В. Г, Линькова Н. С., Ничик Т Е., Хавинсон В. Х. Влияние пептидов на морфофункциональное состояние почек у старых крыс. Успехи геронтол. 2018; 31 (4): 498-504
  9. Kolchina N., Khavinson V., Linkova N., Yakimov A., Baitin D., Afanasyeva A., Petukhov M. Systematic search for structural motifs of peptide binding to doublestranded DNA Nucleic Acids Research. Nucleic Acids Research. 2019; 47 (20): 10553-63.
  10. Vanyushin B.F., Khavinson V.Kh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. Epigenetics - A Different Way of Looking at Genetics. W. Doerfler, P. Böhm (eds.). - Springer International Publishing Switzerland. 2016: 69-90.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russkiy Vrach Publishing House, 2020