Protective effect of bioregulatory peptides on the organotypic tissue culture development in cytostatic presence


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Abstract

The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of healthy cells. Aim of the study. To investigate bioregulatory peptide effects on a decrease of cytostatic inhibition in the culture of different genesis Methods. Organotypic culturing of tissue of the brain cortex, spleen, kidney of Wistar line rats under the presence of cytostatic cyclophosphane (CP) as well the complex and synthesized peptides also were used. Results. The combined effect of complex peptide thymalin or the synthesized peptide KE cytostatic inhibiting effect on the cellular proliferation in the tissues of different genesis is decreased by 14-28%. Conclusion. The obtained data about the effect of bioregulatory peptides create the base for their further investigation as the drugs for the delay of adverse effects by the cytostatic therapy. These drugs can be used in clinical practice for the treatment of cancer patients, receiving cytostatic therapy.

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About the authors

G. A Rizhak

St.Petersburg Institute of Bioregulation and Gerontology

Email: galina@gerontology.ru
Director Assistance of Petersburg Institute of Bioregulation and Gerontology. Petersburg Institute of Bioregulation and Gerontology Russian Federation, Doctor of medical sciences, Professor Dinamo pr., 3, St. Petersburg, 197110, Russian Federation

N. I Chalisova

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Email: ni_chalisova@mail.ru
Expert scientific worker Pavlov Institute of Physiology RAS, Doctor of biologic sciences, Professor Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

O. M Ivko

St.Petersburg Institute of Bioregulation and Gerontology

Email: secretary@gerontology.ru
Senior scientific worker of St.Petersburg Institute of Bioregulation and Gerontology, Candidate of biologic sciences Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

E. S Zalomaeva

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Email: zalomaeva.e@yandex.ru
postgraduate of. Pavlov Institute of Physiology RAS Dinamo pr., 3, St. Petersburg, 197110, Russian Federation

P. N Ivanova

St.Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology

Laboratory worker of Pavlov Institute of Physiology Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; nab. Makarova 6, St. Petersburg, 199034, Russian Federation

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