Features of local expression of mRNA, IL-1 ß, IL-18, CCL2/MCP-1 in modeling pigment epithelium atrophy and retinal degeneration in the experiment on rabbits
- Authors: Neroev V.V.1, Balatskaya N.V.1, Svetlova E.V.1, Neroeva N.V.1, Ryabina M.V.1, Karmokova A.G.1, Losanova O.A.1, Chernomorets I.Y.1, Ilyukhin P.A.1
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Affiliations:
- Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
- Issue: Vol 19, No 2 (2021)
- Pages: 54-62
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113397
- DOI: https://doi.org/10.29296/24999490-2021-02-08
- ID: 113397
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Abstract
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About the authors
Vladimir Vladimirovich Neroev
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: secr@igb.ru
Academician of the RAS, Dr. Med. Sci., Professor, head of the department of pathology of the retina and optic nerve, director Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Natalya Vladimirovna Balatskaya
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: balnat07@rambler.ru
Cand. Biol. Sci., head of the department of immunology and virology Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Elena Victorovna Svetlova
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: qr888@ya.ru
doctor-virologist of the microbiological laboratory. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Natalia Vladimirovna Neroeva
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: nneroeva@gmail.com
Cand. Med. Sci., doctor at department of pathology of the retina and optic nerve. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Marina Vladimirovna Ryabina
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: mryabina@yandex.ru
Cand. Med. Sci., senior researcher at department of pathology of the retina and optic nerve. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Asiyat Gisovna Karmokova
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: asyakarma17@gmail.com
Postgraduate student at department of pathology of the retina and optic nerve. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Oksana Arsenovna Losanova
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: oksana_losanova@mail.ru
Postgraduate student at department of pathology of the retina and optic nerve. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Irina Yuryevna Chernomorets
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: yrgen@mail.ru
trainee-graduate of the department of immunology and virology. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
Pavel Andreevich Ilyukhin
Helmholtz National Medical Research Center of Eye Diseases Ministry of Health of Russia
Email: paulilukhin@gmail.com
Cand. Med. Sci., Researcher, Department of Pathology of the Retina and Optic Nerve. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russian Federation
References
- Machalinska A., Lubinski W., Ktos P., Kawa M., Baumert B., Penkala K., Grzegrzôtka R., Karczewicz D., Wiszniewska B., Machalinski B. Sodium Iodate Selectively Injuries the Posterior Pole of the Retina in a Dose-Dependent Manner: Morphological and Electrophysiological Study Neurochem. 2010; 35: 1819-27. https://doi.org/10.1007/s11064-010-0248-6
- Bhutto I., Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Aspects Med. 2012; 33 (4): 295-317. http://dx.doi.org/10.1016/j.mam.2012.04.005
- Cunha-Vaz J., Bernardes R., Lobo C. Bloodretinal barrier. European J. of Ophthalmology. 2011; 21 (6): 3-9. https://doi.org/10.5301/EJ0.2010.6049
- Öner A. Stem Cell Treatmentin Retinal Diseases: Recen Developments. Turkish J. ofophthalmology 2018; 48 (1): 33-8. https://doi.org/10.4274/tjo.89972
- Kauppinen A., Paterno J.J., Blasiak J., Salminen A., Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cellular and molecular life sciences. 2016; 73 (9): 1765-86. https://doi.org/10.1007/s00018-016-2147-8
- Whitcup S.M., Sodhi A., Atkinson J.P., Holers V.M., Sinha D., Rohrer B., Dick A.D. The role of the immune response in age-related macular degeneration. International J. of inflammation. 2013; 348092. https://doi.org/10.1155/2013/348092
- Doktor F., Prager P., Wiedemann P., Kohen L., Bringmann A., Hollborn M. Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling. Purinergic Signalling. 2018; 14 (4): 471-84. https://doi. org/10.1007/s11302-018-9631-6
- Kerur N., Hirano Y., Tarallo V., Fowler B.J., Bastos-Carvalho A., Yasuma T., Yasuma R., Kim Y., Hinton D.R., Kirschning C.J., Gelfand B.D., Ambati J. TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflamma-some activation in geographic atrophy. Invest Ophthalmol Vis Sci. 2013; 54 (12): 7395-401. https://doi.org/10.1007/978-3-319-17121-0_9
- Kauppinen A., Niskanen H., Suuronen T., Kinnunen K., Salminen A., Kaarniranta K. Oxidative stress activates NLRP3 inflam-masomes in ARPE-19 cells - implications for age-related macular degeneration (AMD) Immunology Letters. 2012; 147 (1-2): 29-33. http://dx.doi.org/10.10Wj. imlet.2012.05.005
- Abe T., Sugano E., Saigo Y., Tamai M. Interleukin -1betta and barrier function of retinal pigment epithelial cells (ARPE-19): Abberant expression of junctional complex molecules. Investigative Ophthalmology & Visual Science. 2003; 44: 4097-104. http://dx.doi.org/10.1167/iovs.02-0867
- Tseng W.A., Then T., Kinnunen K., Lashkari K., Gregory M.S., DAmore P.A., Ksander B.R. NLRP3 inflamasome activation in retinal pigment epithelial cells by lysosomal destabilization: Implication for age-related macular degeneration. Investigative ophthalmology & visual science. 2013; 54 (1): 110-20. https://doi.org/10.1167/iovs.12-10655
- Bamias G., Corridoni D., Pizzaro T.T., Cominelli F New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation. Cytokine. 2012; 59: 451-9. http://dx.doi.org/10.10Wj.cyto.2012.06.014
- Bian Z.M., Elner S.H., Yoshida A., Kinkel S.L., Su J., Elner V.M. Activation of p38, ERK1/2 and NIK pathways is required for IL-1 betta and TNF-alpha-indused chemokine expression in human retinal pigment epithelial cells. Experimental Eye Research. 2001; 73: 111-21. https://doi.org/10.1006/exer.2001.1019
- Narimatsu T., Ozava Y., Miyake S., Hirasava M., Nagai N., Shimmura S., Tsubota K. Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice. Investigative ophthalmology & visual science. 2013; 54: 4555-62. http://dx.doi.org/10.1167/iovs.12-11572
- Luheshi N.M., Kovâcs K.J., Lopez-Castejon G., Brough D., Denes A. Interleukin-1a expression precedes IL-1ß after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. J. of Neuroinflammation. 2011; 8: 186. http://dx.doi.org/10.1186/1742-2094-8-186
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