Metabolic research from the standpoint of personalized medicine

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Abstract

One of the most important tasks of modern medicine is to recognize diseases at the preclinical stage, as well as to assess their development risks and their possible prevention. This dictates the need to use new, modern technologies aimed at the early detection of biomarkers and the identification of new therapeutic targets.

The purpose to summarize the available data on metabolomic studies used in medicine.

Material and methods. The analysis of the main foreign and domestic sources in the PubMed/Medline, RSCI/elibrary databases over the past 5 years was carried out.

Results. Metabolomics is a rapidly developing research method used in biomedicine to illustrate in detail the pathological mechanisms that occur and to develop new disease biomarkers. Analytical approaches used to study the metabolome are not inferior to genetic studies in their specificity and sensitivity. Along with this, the ability to simultaneously quantify several thousand metabolites in samples makes metabolomics a method oriented towards personalized medicine.

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About the authors

Mikhail A. Paltsev

Lomonosov Moscow State University

Author for correspondence.
Email: mpaltzev@gmail.com
ORCID iD: 0000-0002-5737-5706

Director. Center for Immunology and Molecular Biomedicine. Faculty of Biology. Moscow State University. Professor, Doctor of Medical Sciences.

Russian Federation, Leninskie gory, 1, Moscow, 119991

Oxana Yuryevna Zolnikova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: ks.med@mail.ru
ORCID iD: 0000-0002-6701-789X

MD, Professor at the Department of Internal Medicine Propaedeutics, Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Trubetskaya st., 8/2, Moscow, 119991

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