Mitochondrial transport molecules as the potential objects for targeted therapy

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Abstract

Mitochondria are the active cell organelles whose structures (the membrane in particular) express a large number of signaling molecules, proteins mainly, that play an important regulatory role in cell active functioning. The biological activity of mitochondrial proteins suggests their key role as the objects in targeted therapy of mitochondrial functioning processes impaired as the result of the development of infectious, neurodegenerative, stress or pathological process of various etiologies and pathogenesis. Mitochondrial regulatory proteins have recently been of even greater interest and relevance for research, due to their established participation in the pathogenesis of viral infection, oncogenesis and metabolic dysfunctions.

Material and methods. The analysis of the properties of the key signaling molecules of mitochondrial membranes that regulate the transport function of protein compounds in normal and under various pathological conditions was carried out.

Conclusion. The biological properties of the key mitochondrial membrane proteins and their role in the pathogenesis make it relevant to study their verification as possible objects for targeted pharmacotherapy of socially significant diseases based on mitochondrial dysfunction.

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About the authors

Mikhail A. Paltsev

Lomonosov Moscow State University

Author for correspondence.
Email: mpaltzev@gmail.com
ORCID iD: 0000-0002-5737-5706

Director, Center for Immunology and Molecular Biomedicine. Faculty of Biology. Professor, Doctor of Medical Sciences

Russian Federation, Leninskie gory, 1, Moscow, 119991

Tatiana S. Zubareva

St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology

Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-9518-2916

старший научный сотрудник Центра молекулярной биомедицины

Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110

Anna S. Zubareva

St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology

Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-6872-3799

Research assistant, Center of Molecular Biomedicine

Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110

Daria O. Leontyeva

St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology

Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-6981-2531

Research assistant, Center of Molecular Biomedicine

Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110

Ekaterina S. Mironova

St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology

Email: katerina.mironova@gerontology.ru
ORCID iD: 0000-0001-8134-5104

Senior Researcher, Center of Molecular Biomedicine

Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110

Igor M. Kvetnoy

St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint-Petersburg State University

Email: igor.kvetnoy@yandex.ru
ORCID iD: 0000-0001-7302-5581

Head of the Center of Molecular Biomedicine. Professor, Doctor of Medical Sciences

Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; University Emb., 7–9, St. Petersburg, 199034

References

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Nuclear-encoded mitochondrial proteins are imported by multi-subunit translocases (TOM complex). Mitochondrial proteins synthesized in the cytosol are imported into mitochondria post-translationally [3]

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3. Fig. 2. Key cellular functions of the mitochondrial outer membrane peptide Tom70. IMS – intermembrane mitochondria space; MOM – outer membrane of mitochondria; TOM – mitochondrial outer membrane translocase containing the Tom 40 channel-forming protein and the Tom 20 transport receptor [adapted 12]

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4. Fig. 3. Interactions between mitochondrial transport proteins Tom 20 and Tom 70 [adapted 27]

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5. Fig. 4. VDAC1 mediated initiation of apoptosis [adapted 18])

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6. Fig. 5. The process of cell apoptosis involving the DRP1 molecule [adapted 34]

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