Mitochondrial transport molecules as the potential objects for targeted therapy
- Authors: Paltsev M.A.1, Zubareva T.S.2,3, Zubareva A.S.2,3, Leontyeva D.O.2,3, Mironova E.S.2,3, Kvetnoy I.M.2,4
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Affiliations:
- Lomonosov Moscow State University
- St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation
- Saint Petersburg Institute of Bioregulation and Gerontology
- Saint-Petersburg State University
- Issue: Vol 20, No 6 (2022)
- Pages: 3-11
- Section: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/321221
- DOI: https://doi.org/10.29296/24999490-2022-06-01
- ID: 321221
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Abstract
Mitochondria are the active cell organelles whose structures (the membrane in particular) express a large number of signaling molecules, proteins mainly, that play an important regulatory role in cell active functioning. The biological activity of mitochondrial proteins suggests their key role as the objects in targeted therapy of mitochondrial functioning processes impaired as the result of the development of infectious, neurodegenerative, stress or pathological process of various etiologies and pathogenesis. Mitochondrial regulatory proteins have recently been of even greater interest and relevance for research, due to their established participation in the pathogenesis of viral infection, oncogenesis and metabolic dysfunctions.
Material and methods. The analysis of the properties of the key signaling molecules of mitochondrial membranes that regulate the transport function of protein compounds in normal and under various pathological conditions was carried out.
Conclusion. The biological properties of the key mitochondrial membrane proteins and their role in the pathogenesis make it relevant to study their verification as possible objects for targeted pharmacotherapy of socially significant diseases based on mitochondrial dysfunction.
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About the authors
Mikhail A. Paltsev
Lomonosov Moscow State University
Author for correspondence.
Email: mpaltzev@gmail.com
ORCID iD: 0000-0002-5737-5706
Director, Center for Immunology and Molecular Biomedicine. Faculty of Biology. Professor, Doctor of Medical Sciences
Russian Federation, Leninskie gory, 1, Moscow, 119991Tatiana S. Zubareva
St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology
Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-9518-2916
старший научный сотрудник Центра молекулярной биомедицины
Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110Anna S. Zubareva
St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology
Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-6872-3799
Research assistant, Center of Molecular Biomedicine
Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110Daria O. Leontyeva
St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology
Email: cmbm@spbniif.ru
ORCID iD: 0000-0001-6981-2531
Research assistant, Center of Molecular Biomedicine
Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110Ekaterina S. Mironova
St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint Petersburg Institute of Bioregulation and Gerontology
Email: katerina.mironova@gerontology.ru
ORCID iD: 0000-0001-8134-5104
Senior Researcher, Center of Molecular Biomedicine
Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; Dynamo pr., 3, Saint Petersburg, 197110Igor M. Kvetnoy
St. Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation; Saint-Petersburg State University
Email: igor.kvetnoy@yandex.ru
ORCID iD: 0000-0001-7302-5581
Head of the Center of Molecular Biomedicine. Professor, Doctor of Medical Sciences
Russian Federation, Ligovsky prospect, 2–4, St. Petersburg, 191036; University Emb., 7–9, St. Petersburg, 199034References
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