Studying the relationship of iron concentration in blood serum with ferritin, transferrin and other chemical elements
- Authors: Morozova G.D.1,2, Sadykov A.R.3, Logvinenko A.A.4, Namiot E.D.1, Yurasov V.V.3, Skalny A.V.1,5
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Golikov Research Center of Toxicology
- Laboratory of metabolomic diagnostics
- Private healthcare institution «Central clinical hospital «RZD-Medicine»
- Peoples Friendship University of Russia
- Issue: Vol 21, No 2 (2023)
- Pages: 46-51
- Section: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/340879
- DOI: https://doi.org/10.29296/24999490-2023-02-07
- ID: 340879
Cite item
Abstract
Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various analytical techniques is necessary. It is necessary to consider the interactions between iron and other chemical elements that affect the metabolism of iron in the body.
The aim of the study. The aim of the study was to study the relationship between the iron concentration measured by the standard method and the ICP-MS method, with the indicators of ferritin and transferrin in blood serum; study of correlations of iron with other elements in blood serum.
Material and methods. The study was conducted using a database of laboratory tests. In the blood serum of the examined, ferritin, transferrin, iron were measured by the ICP-MS method, the iron colorimetric method (6786, 1809, 13161, 10073 laboratory tests, respectively), as well as other chemical elements by the ICP-MS method. The relationship between the indicators was assessed using the Spearman rank correlation coefficient.
Results. It was shown that the traditionally accepted relationships between the concentrations of iron and ferritin, transferrin are not manifested in the entire range of concentrations of these proteins. At different concentrations of transferrin and ferritin, certain patterns of changes in the concentration of serum iron in men and women were revealed. Statistically significant correlations of iron concentrations in blood serum with zinc, vanadium, selenium, nickel, manganese, magnesium, potassium, iodine, copper, chromium, cobalt, cadmium were determined.
Conclusion. On a large sample the relationship of iron concentrations in blood serum with ferritin, transferrin, and other chemical elements was studied. It is necessary to evaluate the results of measurements of iron metabolism, taking into account the gender of the subject and the presence of interelement interactions.
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About the authors
Galina D. Morozova
I.M. Sechenov First Moscow State Medical University (Sechenov University); Golikov Research Center of Toxicology
Author for correspondence.
Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X
Junior researcher, Laboratory assistant
Russian Federation, Trubetskaya str. 8/2, Moscow, 119991; Bekhtereva str. 1, St. Petersburg, 192019Arsenii R. Sadykov
Laboratory of metabolomic diagnostics
Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427
Data analyst Laboratory of metabolomic diagnostics
Russian Federation, Starokaluzhskoe sh. 63, Moscow, 117630Anna A. Logvinenko
Private healthcare institution «Central clinical hospital «RZD-Medicine»
Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-9788-998X
biologist of the clinical diagnostic laboratory
Russian Federation, Volokolamskoe sh., 84, Moscow, 125367Eugenia D. Namiot
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: enamiot@gmail.com
ORCID iD: 0000-0003-3725-6360
student
Russian Federation, Trubetskaya str. 8/2, Moscow, 119991Vasiliy V. Yurasov
Laboratory of metabolomic diagnostics
Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806
Medical Affairs Director Laboratory of metabolomic diagnostics, Candidate of Medical Sciences
Russian Federation, Starokaluzhskoe sh. 63, Moscow, 117630Anatoly V. Skalny
I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia
Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366
Head of the Center for Bioelementology and Human Ecology, Head of Department of Medical Elementology, Doctor of Medical Sciences, Professor
Russian Federation, Trubetskaya str. 8/2, Moscow, 119991; Mikluho-Maklaya str. 6, Moscow, 117198References
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