MicroRNAs as biomarkers of miocarditis and dilating cardiomiopathy
- Authors: Ryabinina O.M.1, Melnikova E.A.1, Makarova O.V.1
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Affiliations:
- Scientific Research Institute of Human Morphology named after Akad. A.P. Avtsyn FGBNU «Russian Scientific Center of Surgery named after akad. B.V. Petrovsky»
- Issue: Vol 21, No 4 (2023)
- Pages: 20-24
- Section: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/568128
- DOI: https://doi.org/10.29296/24999490-2023-04-03
- ID: 568128
Cite item
Abstract
Introduction. Currently, clinical diagnosis of myocarditis is a difficult task. The diagnosis of the disease is made on the basis of category IV criteria, which include data of electrocardiography, Holter monitoring, echocardiography and MRI, laboratory biomarkers of necrosis, inflammation and heart failure, morphological study of endomyocardial biopsy specimens.
Objective. To analyze literature data on the potential of different miRNAs determination for diagnostics of myocarditis.
Material and methods. Literature search was carried out in Google Scholar for the last 15 years.
Results and discussion. miR-208b in blood mononuclear and cardiac tissues can be considered as a promising marker for myocarditis diagnosis, and circulating miR-27b-3p, miR-126-3p, miR-142- 5p and miR-143-3p for DCM diagnosis. The presence of miR-15b-5p and miR-106a-5p in plasma allows us to distinguish between patients with ischemic and idiopathic DCM. Acute viral myocarditis is characterized by the presence of miR-208b and miR-499-5p in cardiac tissues, while fulminant myocarditis is characterized by increased levels of circulating miR-30a, miR-192, miR-146a, miR-155 and miR-320a. It should be noted that no specific miRNAs for chronic myocarditis have been found.
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About the authors
Olga M. Ryabinina
Scientific Research Institute of Human Morphology named after Akad. A.P. Avtsyn FGBNU «Russian Scientific Center of Surgery named after akad. B.V. Petrovsky»
Email: phlint-grant@yandex.ru
ORCID iD: 0000-0003-2309-5324
Researcher of the A.P. Avtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution «B.V. Petrovsky Russian Scientific Center of Surgery», Ph.D. of Biological Sciences
Russian Federation, Tsyurupy str., 3, Moscow, 117418Ekaterina A. Melnikova
Scientific Research Institute of Human Morphology named after Akad. A.P. Avtsyn FGBNU «Russian Scientific Center of Surgery named after akad. B.V. Petrovsky»
Email: ekaterina@melnikova.online
ORCID iD: 0000-0003-3887-6828
PhD Student of the A.P. Avtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution «B.V. Petrovsky Russian Scientific Center of Surgery»
Russian Federation, Tsyurupy str., 3, Moscow, 117418Olga V. Makarova
Scientific Research Institute of Human Morphology named after Akad. A.P. Avtsyn FGBNU «Russian Scientific Center of Surgery named after akad. B.V. Petrovsky»
Author for correspondence.
Email: makarov.olga2013@yandex.ru
Head of the Laboratory of Immunomorphology of Inflammation of the A.P. Avtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution «B.V. Petrovsky Russian Scientific Center of Surgery», doctor of medical sciences, Professor
Russian Federation, Tsyurupy str., 3, Moscow, 117418References
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