Thyroidogenesis and trace elements: predictor possibilities

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Abstract

Introduction. Trace elements are widely involved in various metabolic processes in humans, including thyroid hormones. Iodine is a part of thyroid hormones, is actively involved in the work of thyroid enzymes, copper, zinc and manganese are included in the composition of antioxidant enzymes, which, in particular, in iron, need the synthesis of hormones.

Purpose: to study the correlation between the levels of trace elements in the blood serum and thyroid hormones and TSH; determination of the prognostic sensitivity of the determination of trace elements, thyroid hormones and TSH in human serum.

Material and methods. The study was performed on the basis of a database of analyzes collected in the course of laboratory practice. Iodine, selenium, copper, zinc, manganese were measured in blood serum by the ICP-MS method, thyroid hormones and TSH were measured by the immunochemiluminescent method. The total number of examined patients was 4162 people. In order to evaluate the quality of models for predicting deficiency or excess of an elevated ratio of thyroid hormones or TSH and vice versa, we used the ROC curve model, which is widely used to determine the diagnostic value of new markers.

Results. The possibility of using TSH as a predictor of iodine deficiency in women was revealed. Also, the content of T4 can be predictors of iodine disease for sexes, and according to the content of total T3 and total T3 can only be predicted by iodine deficiency, also for sexes. Based on the study data, it was revealed that the concentration of thyroid hormones and TSH can be dangerous with the likelihood of an excess or deficiency of selenium, copper, zinc in both women and men. In turn, the level of thyroid hormones and TSH can be called as a predictor of excess or deficiency of sugar in the blood.

Conclusion. Trace elements play an important role in thyroidogenesis and may be useful in the diagnosis and detection of cases of thyroid disease

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About the authors

Anna A. Logvinenko

Private healthcare institution «Central clinical hospital «RZD-Medicine»

Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-9788-998X

biologist of the clinical diagnostic laboratory Private healthcare institution «Central clinical hospital «RZD-Medicine»

Russian Federation, Volokolamskoe sh., 84, Moscow, 125367

Galina D. Morozova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X

Junior researcher I.M. Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Trubetskaya str. 8/2, Moscow, 119991

Vsevolod V. Poleschuk

Research Center of Neurology

Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-7986-1430

neurologist of Research Center of Neurology

Russian Federation, Volokolamskoe sh., 80, Moscow, 125367

Arsenii R. Sadykov

Laboratory of metabolomic diagnostics

Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427

Data analyst Laboratory of metabolomic diagnostics

Russian Federation, Starokaluzhskoe sh. 63, Moscow, 117630

Vasiliy V. Yurasov

Laboratory of metabolomic diagnostics

Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806

Medical Affairs Director Laboratory of metabolomic diagnostics, candidate of Medical Sciences

Russian Federation, Starokaluzhskoe sh. 63, Moscow, 117630

Anatoly V. Skalny

I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia

Author for correspondence.
Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366

Head of the Center for Bioelementology and Human Ecology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Head of Department of Medical Elementology, Peoples Friendship University of Russia, doctor of Medical Sciences, Professor

Russian Federation, Trubetskaya str. 8/2, Moscow, 119991; Mikluho-Maklaya str. 6, Moscow, 117198

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