Study of the relationship between copper and zinc concentrations in blood serum and markers of inflammation

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Abstract

Introduction. According to modern concepts, the inflammatory process is one of the key links in the development of cardiovascular, autoimmune, neurological, oncological diseases, as well as metabolic syndrome, complications of diabetes mellitus, and pathologies of the respiratory system. The implementation of a normal inflammatory response requires metabolic and cellular resources, the functionality of enzymatic and antioxidant systems, which, in turn, depends on the body’s supply of macro- and microelements. Research has shown that zinc and copper are some of the main elements associated with inflammation.

Purpose of the study. The purpose of the study was to examine the relationship between serum copper and zinc concentrations and markers of inflammation.

Material and methods. The study examined correlations between serum copper and zinc concentrations and various measures of inflammation in 1,153 people aged 18 to 86 years. The concentrations of CRP, ESR, ferritin, ceruloplasmin, leukocytes, neutrophils, fibrinogen, uric acid, copper, and zinc were determined in those examined. Serum microelements were measured by ICP-MS; other indicators were determined by standard methods. Correlation analysis was carried out using the Spearman coefficient.

Results. The strongest statistically significant correlations (p<0.05) were found between copper and ceruloplasmin (r=0.612), as well as between copper and CRP (r=0.474) and ESR (r=0.421). Serum copper and zinc showed statistically significant but weak correlations with most inflammatory markers.

Conclusion. The study showed the presence of statistically significant moderate, medium and weak correlations of serum copper and zinc concentrations with inflammation markers, which is due to many intermediate processes and intermediary metabolic reactions between these indicators.

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About the authors

Galina D. Morozova

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University)

Author for correspondence.
Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X

Junior Researcher

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991

Eugenia D. Namiot

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University)

Email: enamiot@gmail.com
ORCID iD: 0000-0003-3725-6360

Student

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991

Elena V. Rylina

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University); Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University"

Email: hellch@mail.ru
ORCID iD: 0000-0002-9375-309X

Leading Researcher, I.M. Sechenov First Moscow State Medical University (Sechenov University); Docent Peoples’ Friendship University of Russia (RUDN University), Candidate of Pharmaceutical Sciences

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991; Miklouho-Maklaya st., 6, Moscow, 117198

Tatyana V. Korobeinikova

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University); Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University"

Email: korobeynikova_t_v@staff.sechenov.ru
ORCID iD: 0000-0002-1373-6354

Head of Molecular Dietetics Laboratory, I.M. Sechenov First Moscow State Medical University (Sechenov University); Docent Peoples’ Friendship University of Russia (RUDN University), Candidate of Technical Sciences

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991; Miklouho-Maklaya st., 6, Moscow, 117198

Anna A. Tsibulina

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University)

Email: anna1268@mail.ru
ORCID iD: 0009-0002-0165-5183

Student

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991

Arsenii R. Sadykov

Laboratory of Metabolomic Diagnostics

Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427

Data Analyst, Laboratory of Metabolomic Diagnostics

Russian Federation, Starokaluzhskoe Shosse, 63, Moscow, 117630

Vasiliy V. Yurasov

Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University"; Laboratory of Metabolomic Diagnostics

Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806

Medical Affairs Director, Laboratory of Metabolomic Diagnostics, Senior Lecturer of Department of Medical Elementology Peoples Friendship University of Russia, Candidate of Medical Sciences

Russian Federation, Miklouho-Maklaya st., 6, Moscow, 117198; Starokaluzhskoe Shosse, 63, Moscow, 117630

Anatoly V. Skalny

First Moscow State Medical University named after I.M. Sechenov, (Sechenov University); Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University"

Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366

Head of the Center for Bioelementology and Human Ecology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Head of Department of Medical Elementology, Peoples Friendship University of Russia, Doctor of Medical Sciences, Professor

Russian Federation, Trubetskaya st., 8, building 2, Moscow, 119991; Miklouho-Maklaya st., 6, Moscow, 117198

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