Neurotropic effects of endogenous compounds – tyronome components in the central nervous system
- Authors: Kudlay D.A.1, Filimonov D.A.2, Morozov V.V.3, Ischenko R.V.2, Eresko A.B.4, Trubnikova N.N.2, Belotserkovskaya M.A.2, Kisilenko I.A.2, Nosova I.N.2
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Affiliations:
- Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
- Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
- ICBFM “Institute of Chemical Biology and Fundamental Medicine” Siberian Branch of the Russian Academy of Sciences
- International Intergovernmental Scientific Research Organization Joint Institute for Nuclear Research
- Issue: Vol 22, No 5 (2024)
- Pages: 3-13
- Section: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/642373
- DOI: https://doi.org/10.29296/24999490-2024-05-01
- ID: 642373
Cite item
Abstract
Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize the biological effects of thyronome components in the central nervous system from the position of their possible role as potential neuroprotectants.
Material and methods. English- and Russian-language full-text articles from PubMed, Mendeley, and e-library electronic databases were selected for analysis using query «(thyroid OR thyroid hormone metabolite OR *-iodo-thyronamine OR thyronamine OR TAAR OR thyronome OR T0AM OR T1AM OR thyroacetic acid) AND (brain OR central nervous system OR CNS OR stroke OR neurodegenerat*)». The search depth amounted to 10 years.
Results. The review systematizes the most important neurotropic properties of 3-T1AM and other thyronome components, including their influence on behavioral effects, memory, pain threshold level, apoptosis, autophagy, and excitotoxic neuronal death, and describes the role of individual receptors and intracellular signal transduction pathways in the realization of these properties.
Conclusion. The components of thyronome, in particular 3-T1AM, demonstrate a wide range of potential neuroprotective properties, and for its potential use in the clinic, it is relevant to find ways to increase local concentration in the brain or permeability to the BBB, as well as the development of more effective synthetic analogues.
Keywords
Full Text

About the authors
Dmitry Anatolyevich Kudlay
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Author for correspondence.
Email: dakudlay@generium.ru
ORCID iD: 0000-0003-1878-4467
Doctor of Medical Sciences, Corresponding Member of the Russian Academy of Sciences, Professor of the Department of Pharmacology, Institute of Pharmacy
Russian Federation, Trubetskaya st., 8, build. 2, Moscow, 119991Dmitry Alexeevich Filimonov
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: dnmu@gmail.com
ORCID iD: 0000-0002-4542-6860
Doctor of Medical Sciences, Deputy Director for Research, Head of the Department of Experimental Surgery
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045Vitaly Valerievich Morozov
ICBFM “Institute of Chemical Biology and Fundamental Medicine” Siberian Branch of the Russian Academy of Sciences
Email: doctor.morozov@mail.ru
ORCID iD: 0000-0002-9810-5593
Doctor of Medical Sciences, Professor, Head of the Laboratory of Experimental and Clinical Medicine
Russian Federation, Ak. Lavrentieva, 8, Novosibirsk, 630090Roman Viktorovich Ischenko
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: ishenkorv@rambler.ru
ORCID iD: 0000-0002-7999-8955
Doctor of Medical Sciences, Director
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045Alexander Borisovich Eresko
International Intergovernmental Scientific Research Organization Joint Institute for Nuclear Research
Email: a_eresko77@jinr.ru
ORCID iD: 0000-0002-3521-5314
Candidate of Chemical Sciences, Senior Researcher, Laboratory of neutron physics
Russian Federation, Joliot Curie St., 6, Dubna, 141980Nadezhda Nicolaevna Trubnikova
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: orenaji3@bk.ru
ORCID iD: 0009-0002-3407-5927
Head of the Laboratory of Basic Research of the Department of Experimental Surgery
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045Margarita Andreevna Belotserkovskaya
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: margarita-amb@mail.ru
ORCID iD: 0009-0004-3019-144X
junior research assistant of the Department of Experimental Surgery
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045Irina Alexandrovna Kisilenko
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: irinka.dn.15@gmail.com
ORCID iD: 0009-0006-6404-2930
junior research assistant of the Department of Experimental Surgery
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045Inna Nicolaevna Nosova
Federal State Budgetary Institution “V.K. Gusak Institute of emergency and reconstructive surgery” of the Ministry of health of the Russian Federation
Email: n_inna_n@mail.ru
ORCID iD: 0009-0005-4868-0345
Junior Research Assistant of the Laboratory of Basic Research of the Department of Experimental Surgery
Russian Federation, Leninsky Avenue, 47, Donetsk, 283045References
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