Peptide stimulation effect on organotypic culture development of neuroendocrine tissues

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Introduction. One of the actual task of modern biology and medicine. Is the creation of bioregulator preparation, which can stimulate the neuroendocrine system of organism.

Purpose of study. Study of effect of polypeptide complex from brain cortex (PPCbc) and from pancreas (PPCp) of calfs on the cellular proliferation in organotypic culture of nerve and endocrine of young and old rats.

Methods. The adequate method of organotypic tissue culture of tissue from young and old rats was used for quick biologically activity of peptides screening.

Results. The square index (SI) of nerve and endocrine tissues explants were increased statistically reliable, as compared to the control, also in young and old rats, under the polypeptides complexes effect.

Conclusion. The data obtained produce the base for working and quick testing of preparations for treatment of patients with pathology in brain cortex and endocrine tissues.

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作者简介

Natalia Chalisova

Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology

编辑信件的主要联系方式.
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043

Doctor of biologic sciences, professor, Expert scientific worker of the I.P. Pavlov Institute of Physiology RAS. Expert scientific worker of the laboratory of Oncogerontology of Biogerontology department of Saint Petersburg Institute of Bioregulation and Gerontology

俄罗斯联邦, nab. Makarova, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110

Galina Ryzhak

Saint Petersburg Institute of Bioregulation and Gerontology

Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438

Doctor of medical sciences, рrofessor, Associate Director

俄罗斯联邦, Ave. Dinamo 3, St. Petersburg, 197110

参考

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  2. Журкович И.К., Ковров Н.Г., Рыжак Г.А., Миронова Е.С., Хавинсон В.Х.Идентификация коротких пептидов в составе полипептидных комплексов, выделенных из органов животных. Успехи современной биологии.2020; 140 (2): 140–8. DOI: 10,31857/ [Zhurkovich I.K., Kovrov N.G., Rizhak G.A., Mironova E.S., Khavinson V. Rh. Identification of short peptides in the composition of polypeptide complexes from animal organs. Advances of modern biol ogy. 2020; 140 (2): 140–8. DOI: 10,31857/ S004213242002012X (In Russian)].
  3. Чалисова Н.И., Концевая Е.А.,Войцеховская М.А. Регуляторное влияние одируемых аминокислот на основные клеточные процессы у молодых и старых животных. Успехи геронтологии. 2011; 21 (1): 189–97. [Chalisova N.I., Koncevaya E.A., Voicekhovskaya M.A. Regulating effect of coded amino acids on main cellular processes in young and old animals. Advance in gerontology. 2011; 21 (1): 189–97 (In Russian)].
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2. Fig. 1. PPCcb influence on SI (square index) of brain of young (1) and old (2) rats, сontrol – zero line (* <0,05)

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3. Fig. 2. Effect of PPCp on SI of pancreas of young (1) and old (2) rats, сontrol – zero line

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