Interaction in the PAMPs – mucosal barrier – cytokines system in children with obesity

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Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes.

Aim of the study. To establish correlations between PAMPs and cytokines in obese children.

Methods. The study included 198 children and adolescents aged 10 to 18 years with various degrees of alimentary-constitutional obesity and children without obesity. The concentrations of cytokines, trephoyl factors and PAMPs were determined by enzyme immunoassay method.

Results. A statistically significant increase in the concentration of IL-17A (p=0.022) was revealed in obese children. When divided by gender, TNFαwas significantly increased in obese boys (p=0.049) and fractalkine in girls (p=0.040).

Conclusion. The interaction in the PAMPs-mucosal barrier-cytokine system in a group of obese children showed the strongest activation of the immune system in obese boys and the escape of inflammation beyond the intestinal barrier, which is enhanced in obesity due to the association, which has pro-inflammatory activity of flagellin with TFF3.

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作者简介

Irina Kirilina

N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation; FSBI “National Medical Research Center of Endocrinology” of the Ministry of Health of the Russian Federation

Email: kirilina-irina@bk.ru
ORCID iD: 0000-0002-3064-6553

Head of the Education Laboratory, Department of oncology, hematology and radiotherapy, junior Researcher

俄罗斯联邦, 117513, Moscow, Ostrovityanova St., 1; 117292, Moscow, Dmitry Ulyanov St., 11

Sergey Rumyantsev

N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation; “Molecular Health Center” LLC; FSBI “National Medical Research Center of Endocrinology” of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: s_roumiantsev@mail.ru
ORCID iD: 0000-0002-7418-0222

Head of the Department of oncology, hematology and radiotherapy, Director, Deputy Director, Doctor of medical sciences, Professor, Corresponding Member of the Russian Academy of Sciences

俄罗斯联邦, 117513, Moscow, Ostrovityanova St., 1; 117218, Moscow, Nakhimovsky Prospekt, 32, room 1, office 25; 117292, Moscow, Dmitry Ulyanov St., 11

Andrey Gaponov

“Molecular Health Center” LLC; Research Institute of General Resuscitation named after V.A. Negovskiy

Email: zorba@yandex.ru
ORCID iD: 0000-0002-3429-1294

Head, Department of Infectious Immunology, Leading Researcher, Federal Scientific and Clinical Center of Resuscitation and Rehabilitation, Candidate of medical sciences

俄罗斯联邦, 117218, Moscow, Nakhimovsky Prospekt, 32, room 1, office 25; 107031, Moscow, Petrovka St., 25/2

Dilyara Khusnutdinova

Kazan (Volga Region) Federal University

Email: dilyahusn@gmail.com
ORCID iD: 0000-0002-9982-9059

Junior Researcher, Research Laboratory «Omics technology», Institute of Fundamental Medicine and Biology

俄罗斯联邦, 420021, Kazan, Parizhskoy Kommuny St., 9

Tatyana Grigorieva

Kazan (Volga Region) Federal University

Email: tatabio@inbox.ru
ORCID iD: 0000-0001-5314-7012

Senior Researcher, Research Laboratory «Omics technology», Institute of Fundamental Medicine and Biology

俄罗斯联邦, 420021, Kazan, Parizhskoy Kommuny St., 9

Elena Teplyakova

FSBEI HE Rostov State Medical University of the Ministry of Health of the Russian Federation

Email: elenatepl7@yandex.ru
ORCID iD: 0000-0002-3585-7026

Professor, Department of Children’s Diseases No.3, Doctor of medical sciences

俄罗斯联邦, 344022, Rostov-on-Don, Nakhichevansky Lane, 29

Aleksandr Shestopalov

N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation; “Molecular Health Center” LLC; FSBI “National Medical Research Center of Endocrinology” of the Ministry of Health of the Russian Federation

Email: al-shest@yandex.ru
ORCID iD: 0000-0002-1428-7706

Head of the Department of biochemistry and molecular biology, Deputy Director, Head of the Laboratory of Biochemistry of Signaling Pathways, Doctor of medical sciences, Professor

俄罗斯联邦, 117513, Moscow, Ostrovityanova St., 1; 117218, Moscow, Nakhimovsky Prospekt, 32, room 1, office 25; 117292, Moscow, Dmitry Ulyanov St., 11

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2. Table 2 Concentrations of PAMPs, trefoil factors and cytokines in blood in the study groups

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3. Table 3 Concentrations of PAMPs, trefoil factors and cytokines in in girls and boys in the study groups

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