DBH gene polymorphism in psoriasis patients


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Abstract

Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatry, there is formed a new scientific field called psychodermatology, which highlights the nature of the link between skin diseases and mental disorders. The aim of the study is to evaluate the role of 3 polymorphic loci in the dopamine beta-hydroxylase (DBH) gene (rs141116007, rs2097629, and rs1611115) in the development of psoriasis. Methods. Genotypes were studied with PCR-RFLP method. Restriction products were separated in 2% agarose gene. Statistical analysis was performed in WinPepi and in APSampler software. Results. We discovered an association of rs1611115:T allele with psoriasis. This allele has a recessive model of inheritance - the presence of C allele reduces risk of psoriasis by 4 times. Complex genotype study revealed an association between rs1611115:TT genotype with psoriasis: p<0,001, OR=3,88. No significant associations were found between rs141116007 and rs2097629. Conclusion. Associated with psoriasis genotype rs1611115:TT is related to decreased DBH activity, increased dopamine concentration and decreased norepinephrine concentration. We suggest altered concentrations of these neuromediators to play a role in the development of psoriasis.

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About the authors

L. R Sakaniya

Centre of Theoretical Problems of Physico-Chemical Pharmacology

Email: vlsobolew@gmail.com
Kosygina st. 4, Moscow, 119991, Russian Federation

A. V Tretiakov

Lomonosov Moscow State University

Email: vlsobolew@gmail.com
Leninskie Gory, 1-12, Moscow, 119234, Russian Federation

A. A Shevtsova

Lomonosov Moscow State University; Center of Experimental Embryology and Reproductive Biotechnologies

Email: vlsobolew@gmail.com
Leninskie Gory, 1-12, Moscow, 119234, Russian Federation; Kostyakova str., 12-4, Moscow, 127422, Russian Federation

Z. G Kokaeva

Lomonosov Moscow State University

Email: vlsobolew@gmail.com
Leninskie Gory, 1-12, Moscow, 119234, Russian Federation

O. I Rudko

Lomonosov Moscow State University

Email: vlsobolew@gmail.com
Leninskie Gory, 1-12, Moscow, 119234, Russian Federation

A. G Soboleva

Centre of Theoretical Problems of Physico-Chemical Pharmacology

Email: vlsobolew@gmail.com
Kosygina st. 4, Moscow, 119991, Russian Federation

I. M Korsunskaya

Centre of Theoretical Problems of Physico-Chemical Pharmacology

Email: vlsobolew@gmail.com
Kosygina st. 4, Moscow, 119991, Russian Federation

E. A Klimov

Lomonosov Moscow State University; Center of Experimental Embryology and Reproductive Biotechnologies; University Diagnostic Laboratory

Email: vlsobolew@gmail.com
Leninskie Gory, 1-12, Moscow, 119234, Russian Federation; Kostyakova str., 12-4, Moscow, 127422, Russian Federation; Shestidesyatiletia Oktyabrya prospect, 18-3, Moscow, 117036, Russian Federation;

V. V Sobolev

Centre of Theoretical Problems of Physico-Chemical Pharmacology; University Diagnostic Laboratory; I.I. Mechnikov Research Institute for Vaccines and Sera

Email: vlsobolew@gmail.com
Kosygina st. 4, Moscow, 119991, Russian Federation; Shestidesyatiletia Oktyabrya prospect, 18-3, Moscow, 117036, Russian Federation; Malyi Kazenny bystreet, 5, Moscow, 105064, Russian Federation

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