Polypeptide effect on stimulation of experimental animals cellular proliferation
- Authors: Ryzhak G.A.1,2,3, Chalisova N.I.1,2,3, Ivanova P.N.1,2,3, Egozova E.S.1,2,3
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Affiliations:
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Saint Petersburg Institute of Bioregulation and Gerontology
- Herzen State Pedagogical University of Russia
- Issue: Vol 21, No 3 (2023)
- Pages: 39-42
- Section: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/568208
- DOI: https://doi.org/10.29296/24999490-2023-03-05
- ID: 568208
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Abstract
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation and apoptosis balanced status in the organism tissues is one of the actual task of modern biology and medicine.
Purpose of study. Effect of polypeptide complexes (PPCs) from liver (Wentwil) and of bladder (Wesustim). and of corresponding short peptides. on the cellular proliferation in liver and bladder tissues of mammalian and birds.
Methods. Organotypic tissue culture of rat and 17-days chick embryo liver, bladder under different PPCs and short peptides was used for quick biologically activity of peptides screening.
Results. The tissue specific effect of PPC and short peptides on liver and bladder of different animals types. The square index (SI) of explants was increased statistically reliable on 21–29%, as compared to the control.
Conclusion. The data obtained produce the base for working and quick testing of preparations for treatment of patients with pathology in liver and bladder tissues.
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About the authors
Galina A. Ryzhak
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438
associate Director of Saint Petersburg Institute of Bioregulation and Gerontology in scientific investigation, doctor of medical sciences, рrofessor
nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Natalia I. Chalisova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
expert scientific worker of the I.P. Pavlov Institute of Physiology RAS, expert scientific worker of the laboratory of Oncogerontology of Biogerontology department of Saint Petersburg Institute of Bioregulation and Gerontology, doctor of biologic sciences, professor
Russian Federation, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Polina N. Ivanova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: ivanovapolina19@mail.ru
ORCID iD: 0000-0001-7112-0673
scientific worker of Petersburg Institute of bioregulation and Gerontology
Russian Federation, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Ekaterina S. Egozova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Author for correspondence.
Email: ekaterina_egozova@mail.ru
ORCID iD: 0000-0002-0055-3778
magister of Herzen State Pedagogical University of Russia
Russian Federation, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186References
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