Peptide stimulation effect on organotypic culture development of neuroendocrine tissues
- Authors: Chalisova N.I.1,2, Ryzhak G.A.2
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Affiliations:
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Saint Petersburg Institute of Bioregulation and Gerontology
- Issue: Vol 22, No 5 (2024)
- Pages: 54-57
- Section: Original research
- URL: https://journals.eco-vector.com/1728-2918/article/view/642402
- DOI: https://doi.org/10.29296/24999490-2024-05-07
- ID: 642402
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Abstract
Introduction. One of the actual task of modern biology and medicine. Is the creation of bioregulator preparation, which can stimulate the neuroendocrine system of organism.
Purpose of study. Study of effect of polypeptide complex from brain cortex (PPCbc) and from pancreas (PPCp) of calfs on the cellular proliferation in organotypic culture of nerve and endocrine of young and old rats.
Methods. The adequate method of organotypic tissue culture of tissue from young and old rats was used for quick biologically activity of peptides screening.
Results. The square index (SI) of nerve and endocrine tissues explants were increased statistically reliable, as compared to the control, also in young and old rats, under the polypeptides complexes effect.
Conclusion. The data obtained produce the base for working and quick testing of preparations for treatment of patients with pathology in brain cortex and endocrine tissues.
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About the authors
Natalia Iosifovna Chalisova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
Doctor of biologic sciences, professor, Expert scientific worker of the I.P. Pavlov Institute of Physiology RAS. Expert scientific worker of the laboratory of Oncogerontology of Biogerontology department of Saint Petersburg Institute of Bioregulation and Gerontology
Russian Federation, nab. Makarova, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110Galina Anatol’evna Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438
Doctor of medical sciences, рrofessor, Associate Director
Russian Federation, Ave. Dinamo 3, St. Petersburg, 197110References
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