THE STATE OF THE PROTEOLYSIS SYSTEM IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA ON THE BACKGROUND OF DIABETES MELLITUS TYPE 2

Ntroduction. The progression of inflammation in community-acquired pneumonia is associated with the activation of proteolytic enzymes, involved in eliminating the pathogenic agent, removing damaged structures. Proteinases are controlled by a-proteinase inhibitor. It is known that in diabetes mellitus (DM) patients as a consequence of microangiopathy, the target for damage is pulmonary tissue, which is accompanied by the risk of developing bronchial asthma, pneumonia. In pneumonia on the background of type 2 diabetes there are poorly expressed symptoms or atypical course of the disease is shown. Therefore, it is promising to search for biochemical indices allowing to identify the features of the course of community-acquired pneumonia on the background of DM type 2. The aim of the study is to evaluate the level of elastase -, trypsin-like proteases and а-PI in the blood plasma of patients with community-acquired pneumonia, DM type 2, as well as in the group of patients with combined pathology of pneumonia and DM type 2. Results: level of α1-PI was maximal in community-acquired pneumonia and amounted to 43.9 МE/ml. The maximum increase of elastase-and trypsin-like proteinases level is observed in the group with combined pathology of pneumonia with DM type 2 and accounts for 145.3 nmol BANE/min·ml and 151.6 nmol BAEE / min·ml, respectively. Conclusion. Pneumonia on the background of DM type 2 occurs most acutely with pronounced destructive processes of the lung tissue, due to a violation of the balance of «proteolysis-anti-proteolysis».

pneumonia, diabetes, proteolysis