Atopic dermatitis: a modern view of intercellular interactions


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Atopic dermatitis (AD) is characterized by a violation of the epidermal barrier dysfunction. This review examines the work of the authors who describe mutations in the filaggrin gene as predisposing factors for the development of AD and describe the dysfunction of the epidermal barrier as a causal mechanism. In recent years, signaling molecules have been widely studied as a key factor in the development of a particular pathology, including signaling molecules of intercellular contacts that play an important role in the pathogenesis of AD. Claudins are the main proteins that make up dense compounds. The analyzed articles in which proteins with dense compounds of claudin-1,7, claudin-10, occludin. It determines the density of these contacts and plays an important role in providing the barrier function. Evaluation of the expression level for further correction of proteins with dense compounds may be an important therapeutic target for targeted therapy of various diseases, including AD.

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作者简介

Ekaterina Iskra

Saint-Petersburg State Pediatric Medical University

Email: e.iskra.doc@mail.ru
postgraduate student of the Department of Pathological Anatomy with the course of Forensic Medicine

Alexander Iskra

Saint-Petersburg State Pediatric Medical University

Email: neonatol@list.ru
postgraduate student of the Department of Rehabilitation of FP and DPO

Vktoriya Polyakova

Saint-Petersburg State Pediatric Medical University

Email: vopol@yandex.ru
Head of the Research Center

Ruslan Nasirov

Saint-Petersburg State Pediatric Medical University

Email: rrmd99@mail.ru
Vice-Rectorfor Research, Head of the Department of Pathological Anatomy with the Course of Forensic Medicine

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