Study of the relationship of iron concentration with the ferritin and transferrin in blood serum

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Introduction. Iron is one of the main elements for the vital activity of the body. Iron deficiency leads to the development of iron deficiency anemia, one of the most common diseases in the Russian Federation; excess iron induces oxidative stress. In this way, the diagnostics of iron metabolism is an important applied problem.

The aim of the study. The aim of the study was to establish reference intervals for serum iron, measured not by the routine method, but by the ICP-MS method, on a large sample; study of gender and age fluctuations of the level of serum iron; study of the relationship between the concentration of iron and the levels of ferritin and transferrin in the blood serum.

Material and methods. The study was performed on the basis of a database of laboratory analyzes. The number of laboratory tests for ferritin, transferrin, iron in serum was 6786, 1809, 13161, respectively. When determining the reference intervals, the Hoffman method was used.

Results. It was found that the concentration of iron in the blood serum among women is lower than among men, and this tendency persists up to 45–50 years, there are no differences in the later age period. The concentration of serum iron positively and statistically significantly correlates with the level of ferritin in all age groups in the total sample and in the group of women; among men, statistically significant positive correlations were found only in the age groups of 18–25 years and older than 56 years. Correlations of iron concentration with the level of transferrin are less intense: statistically significant correlations were found in the total sample in the age groups of 26–35 years and 46–55 years.

Conclusion. When calculating the reference intervals of serum iron, it is necessary to consider the gender and age dynamics of deviations. Aging processes have a greater impact on iron metabolism for women than for men.

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作者简介

Vasiliy Yurasov

Laboratory of metabolomic diagnostics

编辑信件的主要联系方式.
Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806

Medical Affairs Director Laboratory of metabolomic diagnostics. Candidate of Medical Sciences.

俄罗斯联邦, Starokaluzhskoe sh. 63, Moscow, 117630

Arsenii Sadykov

Laboratory of metabolomic diagnostics

Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427

Data analyst Laboratory of metabolomic diagnostics

俄罗斯联邦, Starokaluzhskoe sh. 63, Moscow, 117630

Galina Morozova

Golikov Research Center of Toxicology; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X

Junior researcher Federal State Budgetary Institution «Scientific and Clinical Center of Toxicology named after S.N. Golikov FMBA of Russia». Laboratory assistant I.M. Sechenov First Moscow State Medical University (Sechenov University).

俄罗斯联邦, Bekhtereva str. 1, St. Petersburg, 192019; Trubetskaya str. 8/2, Moscow, 119991

Eugenia Namiot

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: enamiot@gmail.com
ORCID iD: 0000-0003-3725-6360

student I.M. Sechenov First Moscow State Medical University (Sechenov University)

俄罗斯联邦, Trubetskaya str. 8/2, Moscow, 119991

Anna Logvinenko

Private healthcare institution «Central clinical hospital «RZD-Medicine»

Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-9788-998X

biologist of the clinical diagnostic laboratory Private healthcare institution «Central clinical hospital «RZD-Medicine»

俄罗斯联邦, Volokolamskoe sh., 84, Moscow, 125367

Anatoly Skalny

I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia,

Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366

Head of the Center for Bioelementology and Human Ecology, I.M. Sechenov First Moscow State Medical University (Sechenov University). Head of Department of Medical Elementology, Peoples Friendship University of Russia. Doctor of Medical Sciences, Professor.

俄罗斯联邦, Trubetskaya str. 8/2, Moscow, 119991; Mikluho-Maklaya str. 6, Moscow, 117198

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