Studying the relationship of iron concentration in blood serum with ferritin, transferrin and other chemical elements

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Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various analytical techniques is necessary. It is necessary to consider the interactions between iron and other chemical elements that affect the metabolism of iron in the body.

The aim of the study. The aim of the study was to study the relationship between the iron concentration measured by the standard method and the ICP-MS method, with the indicators of ferritin and transferrin in blood serum; study of correlations of iron with other elements in blood serum.

Material and methods. The study was conducted using a database of laboratory tests. In the blood serum of the examined, ferritin, transferrin, iron were measured by the ICP-MS method, the iron colorimetric method (6786, 1809, 13161, 10073 laboratory tests, respectively), as well as other chemical elements by the ICP-MS method. The relationship between the indicators was assessed using the Spearman rank correlation coefficient.

Results. It was shown that the traditionally accepted relationships between the concentrations of iron and ferritin, transferrin are not manifested in the entire range of concentrations of these proteins. At different concentrations of transferrin and ferritin, certain patterns of changes in the concentration of serum iron in men and women were revealed. Statistically significant correlations of iron concentrations in blood serum with zinc, vanadium, selenium, nickel, manganese, magnesium, potassium, iodine, copper, chromium, cobalt, cadmium were determined.

Conclusion. On a large sample the relationship of iron concentrations in blood serum with ferritin, transferrin, and other chemical elements was studied. It is necessary to evaluate the results of measurements of iron metabolism, taking into account the gender of the subject and the presence of interelement interactions.

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作者简介

Galina Morozova

I.M. Sechenov First Moscow State Medical University (Sechenov University); Golikov Research Center of Toxicology

编辑信件的主要联系方式.
Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X

Junior researcher, Laboratory assistant

俄罗斯联邦, Trubetskaya str. 8/2, Moscow, 119991; Bekhtereva str. 1, St. Petersburg, 192019

Arsenii Sadykov

Laboratory of metabolomic diagnostics

Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427

Data analyst Laboratory of metabolomic diagnostics

俄罗斯联邦, Starokaluzhskoe sh. 63, Moscow, 117630

Anna Logvinenko

Private healthcare institution «Central clinical hospital «RZD-Medicine»

Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-9788-998X

biologist of the clinical diagnostic laboratory

俄罗斯联邦, Volokolamskoe sh., 84, Moscow, 125367

Eugenia Namiot

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: enamiot@gmail.com
ORCID iD: 0000-0003-3725-6360

student

俄罗斯联邦, Trubetskaya str. 8/2, Moscow, 119991

Vasiliy Yurasov

Laboratory of metabolomic diagnostics

Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806

Medical Affairs Director Laboratory of metabolomic diagnostics, Candidate of Medical Sciences

俄罗斯联邦, Starokaluzhskoe sh. 63, Moscow, 117630

Anatoly Skalny

I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia

Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366

Head of the Center for Bioelementology and Human Ecology, Head of Department of Medical Elementology, Doctor of Medical Sciences, Professor

俄罗斯联邦, Trubetskaya str. 8/2, Moscow, 119991; Mikluho-Maklaya str. 6, Moscow, 117198

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