The gender factor effect for the edocryne function of mesenchymal tissues in children and adolescent

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Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon.

The aim of study. The purpose of that work is comparative analysis of metabolic status, as well as content of adipokines, myokines and some hormones in the blood of children and adolescents with obesity, dependent of gender.

Methods. Quantification of the adipokines, myokines and hormones was carried out using multiplex ELISA.

Results. Studies have revealed gender differences in the level of certain hormones, adipokines, and myokines, suggesting the appearance of features in the development of obesity in boys and girls. Obese girl experience compensatory changes that help limit manifestation of insulin resistance and lipotoxicity, as well as cardioprotective and neuroprotective effects. This prevents them from serious complications from the cardiovascular and central nervous system in obesity. In boy, due to the formation of gender peculiarities in the production of hormones, adipokines, and myokines, with obesity there are propose for appearance of a number of complications that worse the prognosis of disease in terms of development of its complications – type II diabetes mellitus and atherosclerosis.

Conclusion. The development of obesity in children and adolescents is accompanied by the appearance of gender peculiarities on the part of the endocrine function of mesenchymal tissues.

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作者简介

Alexander Shestopalov

Pirogov Russian National Research Medical University, , Russian Federation; Center of Digital and Translational Biomedicine «Сenter of Molecular Health»; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Email: al-shest@yandex.ru
ORCID iD: 0000-0002-1428-7706

Holder of the department of biochemistry and molecular biology, Vice director of the Center of Digital and Translational Biomedicine, Holder of the department of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. Doctor of Medical Sci., professor

俄罗斯联邦, Ostrovityanova st., 1, Moscow, 117997; Nakhimovski av., 32, 1, Moscow, 117218; Samory Mashela st., 1, Moscow, 117997

Vadim Davydov

Pirogov Russian National Research Medical University

Email: vaddavydov@mail.ru
ORCID iD: 0000-0002-3347-1832

professor of the department of biochemistry and molecular biology, Doctor of Medical Sci., professor

俄罗斯联邦, Ostrovityanova st., 1, Moscow, 117997

Genrik Tumanyan

The Rostov State Medical University

Email: henrik1995@mail.ru
ORCID iD: 0000-0002-4428-4477

pediatrian

俄罗斯联邦, Nakhichevansky st., 29, Rostov-na-Donu, 344022

Dmitriy Savchuk

The Rostov State Medical University

Email: dr.savchyk@mail.ru
ORCID iD: 0000-0003-0594-3385

pediatrian

俄罗斯联邦, Nakhichevansky st., 29, Rostov-na-Donu, 344022

Elena Teplyakova

The Rostov State Medical University

Email: mzro@aaanet.ru
ORCID iD: 0000-0002-3585-7026

professor of the Department of Children’s Diseases, Doctor of Medical Sci.,professor

俄罗斯联邦, Nakhichevansky st., 29, Rostov-na-Donu, 344022

Vladimir Shin

5The Rostov State Medical University

Email: shinmz@mail.ru
ORCID iD: 0000-0002-7111-3366

assistant professor of the department of polyclinic and Emergency pediatrics

俄罗斯联邦, Nakhichevansky st., 29, Rostov-na-Donu, 344022

Tatiana Grigoryeva

Kazan Federal University

Email: tatabio@inbox.ru
ORCID iD: 0000-0001-5314-7012

leading researcher, Candidate of Biological Sciences

俄罗斯联邦, Kremlyovskaya str., 18, Kazan, 420008

Alexander Laikov

4Kazan Federal University

Email: alexander.laikov@yandex.ru
ORCID iD: 0000-0002-4250-2645

researcher

俄罗斯联邦, Kremlyovskaya str., 18, Kazan, 420008

Olga Borisenko

Pirogov Russian National Research Medical University

Email: borisenko_olga07@mail.ru
ORCID iD: 0000-0001-8007-6045

assistant professor of the department of biochemistry and molecular biology, Candidate of Biological Sciences

俄罗斯联邦, Ostrovityanova st., 1, Moscow, 117997

Sergey Roumiantsev

Pirogov Russian National Research Medical University; Center of Digital and Translational Biomedicine «Сenter of Molecular Health»

编辑信件的主要联系方式.
Email: s_roumiantsev@mail.ru
ORCID iD: 0000-0002-7418-0222

Holder of the department of oncology, hematology and radiation therapy, Director of the Center of Digital and Translational Biomedicine, Holder of the department of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Corresponding member of the Russian Academy of Sciences. Doctor of Medical Sci., professor

俄罗斯联邦, Ostrovityanova st., 1, Moscow, 117997; Nakhimovski av., 32, 1, Moscow, 117218

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