The Role of P2X7 Receptors in the Pathogenesis of Depression and Autism Spectrum Disorders

封面
  • 作者: Panyukov V.A.1, Zakharova V.A.1,2, Malinovskaya N.A.1,2, Shogenov Z.I.3, Nicheporenko Y.A.4, Shikhmagomedova A.R.5
  • 隶属关系:
    1. Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation
    2. Siberian Federal University
    3. Federal State Budgetary Educational Institution of Higher Education “Kabardino-Balkarian State University named after H.M. Berbekov”
    4. Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
    5. Federal State Budgetary Educational Institution of Higher Education «Dagestan State Medical University» of the Ministry of Health of the Russian Federation
  • 期: 卷 23, 编号 4 (2025)
  • 页面: 64-74
  • 栏目: Reviews
  • URL: https://journals.eco-vector.com/1728-2918/article/view/689189
  • DOI: https://doi.org/10.29296/24999490-2025-04-10
  • ID: 689189

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详细

Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders.

The purpose of this literature review was a systematic analysis of information in the modern scientific literature devoted to the role of the P2X7 subtype of purinergic receptors in the pathogenesis of depression and autism spectrum disorders.

Material and methods. The literature review includes data from foreign and domestic articles published in PubMed and eLibrary over the past 23 years, which are devoted to purinergic signals associated with P2X7 receptors, in health and in depression, autism spectrum disorders.

Results. P2X7 receptors are unique representatives of the P2X receptor family, normally involved in the regulation of immune processes, maintenance of cellular homeostasis and neuronal plasticity, promoting the balance between inflammatory reactions and recovery mechanisms. Hyperactivation of this type of receptors under stress or inflammation leads to a cascade of pathological processes, including neuroinflammation, disruption of synaptic plasticity and cotransmitter properties, development of oxidative stress, which play a key role in the development of the considered mental disorders, which is associated with the activation of the P2X7-NLRP3-cytokines IL-1βand IL-18 pathway. The established patterns confirm the pathogenetic role of P2X7 receptors in the development of depression and autism spectrum disorders.

Conclusion. The presented analysis demonstrates a significant pathogenetic role of P2X7 receptors in the development of depression and autism spectrum disorders. An interesting perspective is the potential therapeutic modulation of P2X7 activity and the study of models for translational research. Future studies should focus on the long-term safety and efficacy of P2X7 inhibitors, as well as their interaction with other approaches, which may significantly improve the quality of life of patients with autism.

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作者简介

Vladislav Panyukov

Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: panyuckovvladislav@yandex.ru
ORCID iD: 0000-0003-2079-4525
SPIN 代码: 9702-9645

Postgraduate Student, Assistant of the Department of Biological Chemistry with courses in medical, pharmaceutical and toxicological chemistry

俄罗斯联邦, Partizana Zheleznyaka St., 1, Krasnoyarsk, 660022

Valeria Zakharova

Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation; Siberian Federal University

Email: valeria.zaxarova.2019@mail.ru
ORCID iD: 0009-0007-0691-868X

Senior Laboratory Assistant of the Department of Biological Chemistry with courses of medical, pharmaceutical and toxicological chemistry

俄罗斯联邦, Partizana Zheleznyaka St., 1, Krasnoyarsk, 660022; Svobodny Ave., 79, Krasnoyarsk, 660041

Natalia Malinovskaya

Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation; Siberian Federal University

Email: malinovskaya-na@mail.ru
ORCID iD: 0000-0002-0033-3804
SPIN 代码: 3474-5990

Doctor of Medical Sciences, Head of the Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry

俄罗斯联邦, Partizana Zheleznyaka St., 1, Krasnoyarsk, 660022; Svobodny Ave., 79, Krasnoyarsk, 660041

Zaur Shogenov

Federal State Budgetary Educational Institution of Higher Education “Kabardino-Balkarian State University named after H.M. Berbekov”

Email: zaur.shogenov.2002@mail.ru
ORCID iD: 0009-0001-5143-3733

5thyear student

俄罗斯联邦, Chernyshevsky Street, 173, Nalchik, 360004, Kabardino-Balkarian Republic

Yulia Nicheporenko

Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation

Email: nicheporenko.yulia@yandex.ru
ORCID iD: 0009-0008-7259-1432

5thyear student

俄罗斯联邦, Ostrovityanova Street, 1, Building 6, Moscow, 117513, Russian Federation

Aina Shikhmagomedova

Federal State Budgetary Educational Institution of Higher Education «Dagestan State Medical University» of the Ministry of Health of the Russian Federation

Email: ayna.shikhmagomedova@mail.ru
ORCID iD: 0009-0007-6472-3362

6thyear student

俄罗斯联邦, Lenin Square, 1, Makhachkala, Republic of Dagestan, 367000

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2. Fig. 1.Classical classification scheme of nucleotide receptors (left) and reclassification (right) of purinergic P2 receptors. The figure was made by the authors of the article during the analysis of literature sources [1–5]

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3. Fig. 2.The structure of the subunits of the P2X receptors (left, general structure plan) and the P2X7 receptor (right, general structure plan and display of the location in the cell membrane). The figure was made by the authors of the article during the analysis of literature sources [5–9]

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4. Fig. 3.Formation of a low-conductivity cation-selective channel (left, subunit trimer shown) or a high-conductivity non-selective pore (right, subunit tetramer shown) from P2X receptor subunits. The figure was made by the authors of the article during the analysis of literature sources [5, 8, 9, 13]

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