Serotonin as a modulator of neurogenesis processes in post-traumatic stress disorder

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The purpose of this review is to discuss the role of serotonin in the processes of neurogenesis in the hippocampus in post-traumatic stress disorder. Full-text materials were searched in Medline (PubMed) and Scopus databases over the past 15 years.

Results. Cognitive impairment that occurs in post-traumatic stress disorder (PTSD) is associated with a decrease in the level of neurogenesis in the dentate gyrus of the hippocampus and disruption of the monoaminergic brain systems: catecholamines and serotonin. Animal studies using the Single Prolonged Stress (SPS) protocol confirm PTSD-like symptoms, decreased levels of neurogenesis and serotonin in the hippocampus, and the use of Tph1-/-, Tph2-/-, Tph1/Tph2-/-, TetO-shTph2 models allow us to suggest that serotonin does not play a major role in maintaining the basal level of neural stem cell (NSC) proliferation, but is required to modulate neurogenesis in response to changed conditions (physical activity, enriched environment). Modulation of neurogenesis probably occurs through activation of serotonin receptors located on both NSCs and glial cells, of which 5-HTR1 and 5-HTR2 are of greatest interest.

Conclusion: Serotonin modulates the processes of neurogenesis in the hippocampus in response to changing environmental conditions through activation of receptors 5-HTR1 and 5-HTR2.

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作者简介

Ekaterina Kurilova

Immanuel Kant Baltic Federal University

编辑信件的主要联系方式.
Email: ekaterinakuuurilova@gmail.com

Postgraduate Student of High School of life sciences, Institute of Medicine and Life Sciences (MEDBIO), Laboratory for Synthetic biology

俄罗斯联邦, ul. Universitetskaya, 2, Kaliningrad, 236041

Maria Sidorova

Immanuel Kant Baltic Federal University

Email: sidorova.mari@list.ru
ORCID iD: 0000-0003-3347-2920

Senior Lecturer, Educational and scientific cluster “Institute of Medicine and Life Sciences (MEDBIO)”, High School of life sciences, Laboratory for Synthetic biology

俄罗斯联邦, ul. Universitetskaya, 2, Kaliningrad, 236041

Oksana Tuchina

Immanuel Kant Baltic Federal University

Email: otuchina@kantiana.ru
ORCID iD: 0000-0003-1480-1311

Head of laboratory for Synthetic biology, Institute of Medicine and Life Sciences (MEDBIO), Candidate of Biological Sciences, Associate Professor

俄罗斯联邦, ul. Universitetskaya, 2, Kaliningrad, 236041

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