The rate and location of thepositive surgical margin and its role in predicting recurrence of prostatic cancer


Cite item

Full Text

Abstract

To estimate the rate of positive surgical margin (SM) in radical retropubic
prostatectomy and its role in emergence of prostatic cancer (PC)
recurrence, we operated 216 PC patients aged 41 to 73 years. Most of
the patients had clinical stages T2a,b (41.8%) or T3a (35.6%). Stages Tl
and T3b were in 18.7 and 3.9% patients, respectively .A positive SM was
Г registered in 68 of 193 patients (35.2%). Thirty six (52.9%) patients had
a focal (solitary or short) SM, thirty two (47.1%) had a long SM. The
recurrence occurred in 31 (16.1%) patients who, as a rule, had long SM.
Recurrence-free one-year survival in 104 patients who had no SM
reached 82%, in 34 patients with focal SM (group 2) it was 83%. Such
three-year survival in group 1 and 2 was 75 and 73.6%, respectively.
Thus, recurrence-free survival in organ-limited process and short SM
differed little within 3 years. The period between 12 and 24 months of
follow-up is most risky in relation to detection of recurrence in short SM.
The group of patients with long SM had maximal number of recurrences.

About the authors

E I Veliev

S В Petrov

О В Loran

References

  1. Park E. L., Dalkin В., Escobar C., Nagle R. B. Site-specific positive margins at radical prostatectomy: assessing cancer-control benefits of wide excision of the neurovascular bundle on a side with cancer on biopsy. Br. J. Urol. Int. 2003; 91 (3): 219-222.
  2. Epstein J. I. Incidence and significance of positive margins inradical prostatectomy specimens. Urol. Clin. N. Am.1996; 23 (4): 651-663.
  3. Sofer M., Hamilton-Nelson K. L., Civantos F., Soloway M. S. Positive surgical margins after radical retropubic prostatectomy: the influence of site and number on progression. J. Urol (Baltimore). 2002; 167 (6): 2453-2456
  4. Ayala A. G., Ro J. Y., Babaian R. et al. The prostatic capsule: does it exist? Am. J. Surg. Pathol. 1989; 13 (1): 21-27.
  5. Epstein J. L. Evaluation of radical prostatectomy capsular margins of resection: The significance of margins designated as negative, closely approaching, and positive. Am. J. Surg. Pathol. 1990; 14 (3): 621-626.
  6. Epstein J. L., Carmichael M. J., Pizov G., Walsh P. С. Influence of capsular penetration on progression following radical prostatectomy: a study of 196 cases with long-term followup. J. Urol.(Baltimore) 1993; 150 (1): 135-141.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies