Renal tumor size. Clinicomorphological correlations
- Authors: Seregin AV1, Loran OB1, Ashugyan VR1, Seriogin AV1, Loran OB1, Ashugyan VR1
-
Affiliations:
- Issue: No 3 (2009)
- Pages: 42-48
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/277399
- ID: 277399
Cite item
Full Text
Abstract
To reveal correlations between a renal tumor size and its clinical and morphological characteristics, we retrospectively analysed 263 case histories of patients with renal cell cancer. At a univariate analysis a maximal renal tumor size as a continuous variable significantly correlated with tumor differentiation, histological involvement of regional lymph nodes, presence of tumor necrosis, venous thrombosis, invasion into the collecting system, severity of clinical symptoms, 3- and 5-year cancer-specific survival. An increase of a tumor size, either as a continuous variable or a categorical one is accompanied with enhancement of tumor properties determining the outcome. The inclusion of a tumor size as a continuous parameter in the staging systems may have in the future a significant impact on accuracy of prediction of a renal cell cancer course and outcome, on specification of indications for various treatments.
References
- Аляев Ю. Г. Диагностика и лечение опухоли почки. В кн.: Пленум Всероссийского о-ва урологов: Тезисы докладов. Кемерово; 1995. 4-32.
- Аляев Ю. Г., Крапивин А. А. Резекция почки при раке. М.: Медицина; 2001.
- Серегин А. В. Органосохраняющие операции при раке почки: Дис. ... д-ра мед. наук. М.; 2000.
- Лопаткин Н. А., Козлов В. П., Гришин М. А. Рак почки: Нефрэктомия или резекция. Урол. или нефрол. 1992; 4: 3-6.
- Лоран О. Б., Пушкарь Д. Ю., Гумин Л. М. К вопросу о выборе хирургического доступа при лечении опухолей почек. Анналы хир. 2001; 1: 70-74.
- Available at URL: http://www.seer.cancer.gov/. Accessed 2006.
- Patard J.-J. With increasing minimally invasive options for small renal tumours, it is time to develop patient-specific treatment strategies. Eur. Urol. 2007; 51: 876-878.
- Murphy A. M., Gilbert S. M., Kaz A. E. et al. Re-evaluation of the Tumour-Node-Metastasis staging of locally advanced renal cortical tumours: absolute size (T2) is more significant than renal capsular invasion (T3a). Br. J. Urol. Int. 2005; 95 (1): 27-30.
- Hsu R. M., Chan D. Y., Siegelman S. S. Small renal cell carcinomas: Correlation of size with tumor stage, nuclear grade, and histologic subtype. Am. J. Roentgenol. 2004; 182: 551-557.
- Schachter L. R., Bach A. M., Snyder M. E. et al. The impact of tumour location on the histological subtype of renal cortical tumours. B. J. Urol.; 98 (1): 63-66.
- Schips L., Lipsky K., Zigeuner R. Impact of tumor-associated symptoms on the prognosis of patients with renal cell carcinoma: a single-center experience of 683 patients. Urology 2003; 62: 1024-1028.
- Ficarra V., Prayer-Galetti T., Novara G. et al. Tumor-size breakpoint for prognostic stratification of localized renal cell carcinoma. Urology 2004; 63: 235-240.
- Ficarra V., Novara G., Galfano A., Artibani W. Neoplasm staging and organ-confined renal cell carcinoma: a systematic review. Eur. Urol. 2004; 46: 559-564.
- Ficarra V., Guille F., Schips L.et al. Proposal for revision of the TNM classification system for renal cell carcinoma. Cancer 2005; 104: 2116-2123.
- Steiner T., Knels R., Schubert J. Prognostic significance of tumour size in patients after tumour nephrectomy for localized renal cell carcinoma. Eur. Urol. 2004; 46: 327-330.
Supplementary files
