Efficacy of uro-vaxom in recurrent infectious-inflammatory diseases of the urogenital system


Cite item

Full Text

Abstract

Our study prospects of urovaxom in improvement of efficacy and prevention of recurrent urogenital infection. One capsule of oral vaccine uro-vaxom was given daily for a month to 127 patients: 23 males with chronic bacterial prostatitis/urethroprostatitis, 75 females with chronic cystitis, 29 females with urolithiasis complicated with secondary chronic pyelonephritis. Control examination was made each two months for a year. In signs of inflammation the patients received one more course of uro-vaxom for a month. It was followed by control examinations each three month for a year. We observed a 6-12 month "cold" period after one course of uro-vaxom in 86.7% patients. After the second course of immunoprophylaxis recurrent urogenital infection occurred 8 times less often. Thus, immunoprophylaxis of urogenital infection with oral vaccine uro-vaxom is highly effective, is well tolerated and, therefore, must enter the standards of medical care for patients with urogenital infection.

References

  1. Naber K. G., Cho Y. H., Matsumoto Т., Schaeffer A. S. Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis. Int. J. Antimicrob. Agents 2009; 33(2): 111-119.
  2. Krieger J. N. Urinary tract infections: what's new? Urol. (Baltimore) 2002; 168: 2351-2358.
  3. Nicolle L. E. Asymptomatic bacteriuria in the elderly. Infect. Dis. Clin. N. Am. 1997; 11: 647-662.
  4. Kun Suk Kim, Ji-Yoon Kim, In Gab Jeong et al. A prospective Multi-center Trial of Escherichia coli extract for the prophylactic treatment of patients with chronically recurrent cystitis. J. Korean Med. Sci. 2010; 25: 435-439.
  5. Huber M., Krauter K., Winkelmann G. et al. Immunostimulation by bacterial components: II. Efficacy studies and meta-analysis of the bacterial extract OM-89. Int. J. Immunopharmacol. 2000; 22: 1103-1111.
  6. Bauer H. W., Rahls W., Lauener P. A., Plessmann G. S. Prevention of recurrent urinary tract infections with immuno-active E. Coli fractions: a meta-analysis of five placebo-controlled double-blind studies. Int. J. Antimicrob. Agents 2002; 19(6): 451- 456.
  7. Schmidharnmer S., Ramoner R., Holtl L. et al. An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells. Urol. 2002; (3); 606: 521-526.
  8. Thilagarajah R., Witherow R. O., Walker M. M. Quantitative hystopathology can aid diagnosis in painful bladder syndrome. J. Clin. Pathol. 1998; 51: 211-214.
  9. Schulman C. C., Corbusier A., Michiels H., Taenzer H. J. Oral immunotherapy of recurrent urinary tract infections: a double-blind placebo-controlled multicenter study. J. Urol. (Baltimore) 1993; 150: 917-921.
  10. Magasi P., Panovics J., Illes A, Nagy M. Uro-Vaxom and the management of recurrent urinary tract infection in adults: a randomizes multicenter double-blind trial. Eur. Urol. 1994; 26: 137-140.
  11. Hachen H. J. Oral immunotherapy in paraplegic lpatients with chronic urinary tract infections: a double-blind, placebo-controlled trial. J. Urol. (Baltimore) 1990; 143: 759-763.
  12. Tammen H. The German urinary tract infection study group. Immunobiotherapy with Uro-Vaxom in recurrent urinary tract infection. Br. J. Urol. 1990; 65: 6-9.
  13. Schneider H.-J. New therapeutic approach for recurrent urinary tract infections. Marked reduction in recurrence rate in women with uncomplicated cystitis - few side effects, high compliance. Allgemeinarzt 1990; 12: 626-633.
  14. Popa G., Lauber K.-D., Rothe H., Rugendorff E. Rezidivierende Harnwegsinfektionen in der Postmenopause. Wirksamkeit einer oralen Immuntherapie mit E. Coli-fraktionen. Münch. Med. Wschr. l996; 138: 713-716.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies