Comparative clinical and morphological characteristics of incidental and symptomatic renal cell carcinoma
- Authors: Trapeznikova M.F1, Kazantseva I.A1, Tyan P.A1, Dutov V.V1
-
Affiliations:
- Issue: No 5 (2013)
- Pages: 6-11
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/279943
- ID: 279943
Cite item
Open Access
Access granted
Abstract
Over the last two decades, marked increase in detection of incidental or asymptomatic renal cell carcinoma (RCC) in developed countries was observed. The study included 268 patients aged from 25 to 92 years with RCC, which underwent evaluation and treatment in urology clinic MRSRCI for the past 5 years. There were no significant differences in the frequency of histological types of RCC between incidental and symptomatic tumors. Among incidental neoplasms with clear- cell structure, tumor with small size — up to 4 cm (T1a stage) and moderate to high degree of differentiation (G 1-2 according Fuhrman) were predominant. Papillary variant of RCC was detected at a higher stage of the disease and characterized by a high degree of nuclear atypia, which indicates its high malignant potential. Chromophobe RCC was usually diagnosed at T3 stage. The average age of men and women with chromophobe RCC was 46,5±6,8 years; there were no age difference in patients with symptomatic and incidental RCC. Among the benign tumors of the kidneys, angiomyolipoma was most commonly diagnosed — in 13 (53,8 %) cases. Thus, incidental tumors have a better prognosis than symptomatic tumors.
Keywords
Full Text
References
- Зубарев А.В., Гажонова В.Е., Зайцева Е.В. Диагностические возможности магнитно-резонансной, ультразвуковой и рентгеновской ангиографии при исследовании сосудов почек. Мед. визуализация. 2003; 1:106—119.
- Kytikov A. et al. Incidence of beging pathologic findings at partial nefrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperated imaiging. Urology. 2006;68(4):737—740.
- Jayson M., Sanders H. Increased incidence of serendipitously discovered renal cell carcinoma. Urology. 1998;51:203—205.
- Bretheau D. et al. Prognostic value of nuclear grade of renal cell carcinoma. Cancer. 1995;76(12):2543—2549.
- Rodriguez-Rubio F. et al. Incidentally detected renal cell carcinoma. Br J Urol. 1996;78:29—32.
- Marcos F., Dall'oglio, Miguel Srougi, Pierre d. et al. Morphologic of incidentally inentified renal tumors. Brazilian J Urol. 2002;28(2):102—108.
- Гусев А.А. Клинико-морфологические особенности инцидентального почечно-клеточного рака. Автореф. дис. канд. мед.наук. М., 2007. 22 с.
- Mevorach R.A., Segal A.J., Terswgno M.E. et al. Renal cell carcinoma: incidental diagnosis and natural history: review of 235 cases. Urology. 1992;39(6):519—522.
- Patard J.J. et al. Prognostic significance of the mode of detection in renal tumours. BJU International. 2002;90(4):358—363.
- Luciana L.G., Cestari R., Tallarigo C. Incidental renal cell carcinoma — age and stage characterization and clinical implications: study of 1092 patients (1982—1997). Urology. 2000;56:58—62.
Supplementary files
