EXPERIENCE IN THE TREATMENT OF AUTOIMMUNE MALE INFERTILITY IN PATIENTS WITH CATEGORY 4 CHRONIC PROSTATITIS


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Abstract

Administration of longidaza at a dose of 3000 IU intramuscularly twice a week after 1 month of treatment leads to the statistically significant reduction of antisperm antibodies (ASAB) at the surface of sperm cells to 23% (7-48%) for MARIgG and to 14.5% (3-34% ) for MARIgA. Maximum reduction of ASAB, however, was observed after third month of treatment, mean MARIgG was 2% (1-26,5%) and MARIgA - 1% (0-11.5%). ASAB level has not reduced less than 50% only in one patient (1.67%). At follow-up three months after the cancellation of Longidaza, only 17 (28.33%) men showed an increase of ASAB IgG and (or) IgA more than 50%. In the study group during the observation, spontaneous pregnancy occurred in 6 (10%) pairs, and IVF was successfully performed in 3 (5%) pairs. Thus, we consider it necessary to appoint Longidaza in patients with category 4 chronic prostatitis and elevated levels of antisperm antibodies on sperm cells, who preparing for assisted reproductive technologies, or preparing for natural pregnancy, as a high-effective pathogenetical agent for the treatment of autoimmune infertility.

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About the authors

D. G Pochernikov

SBEI HPE «Ivanovo State Medical Academy» of RMPH

Email: urologkmn@maiI.ru
Department of Faculty Surgery and Urology

E. Yu Vinokurov

SBEI HPE «Ivanovo State Medical Academy» of RMPH

Department of Faculty Surgery and Urology

A. I Strelnikov

SBEI HPE «Ivanovo State Medical Academy» of RMPH

Department of Faculty Surgery and Urology

L. V Yakovleva

SBEI HPE «Ivanovo State Medical Academy» of RMPH

Department of Faculty Surgery and Urology

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