RISK FACTORS FOR ANTERIOR URETHRAL STRICTURES AFTER TRANSURETHRAL RESECTION OF BENIGN PROSTATIC HYPERPLASIA

Objective: To determine the risk factors for anterior urethral strictures after transurethral resection of benign prostatic hyperplasia. Materials and Methods: The present study consists of a prospective and retrospective part. Prospective analysis of 110 patients who had undergone, at the urology clinic of First MSMU named after I.M. Sechenov in the period from January 2009 to February 2014 was performed transurethral resection (TUR) of the prostate. In the retrospective part, the case histories of 85 patients who were treated in the urology clinic First MSMU named after I.M. Sechenov from 2009 to 2013 with a diagnosis of urethral stricture were analysed. Of them, 29 cases urethral stricture occurred earlier after undergoing TURP. Patients from both sides were divided into two groups: group number 1 patients undergoing TURP for BPH who have not formed a urethral stricture, and group number 2 - patients who had urethral stricture formed. Results: According to the criteria for inclusion in group number 1there were 40 patients who did not form a urethral stricture after TURP and 33 patients were included in the group number 2, in which the late postoperative period was complicated by the formation of a stricture of the urethra. Prostate volume was significantly different in both groups. In group number 1 prostate volume averaged 60 cm3+23 cm3 in group number 2 prostate size equaled an average of 80 cm3+24 cm3. (p<0,05). Having a urethral catheter or cystostomic drainage before surgery was observed in 12% (n=5) in the first group and 27% (n=9) in the second group. Duration of operative benefits was assessed at intervals up to 60 minutes and more than 60 minutes. Thus, the results in the first group are divided into 75% (30) 25% (10), respectively. In the second group, these values were 24,2% (n=8) and 75.8% (n=25). Diabetes mellitus was noted in a first group in 12.5% (n=5) of the patients, in the second group - 30% (n=10). The number of patients seen earlier for hypertension in the group, which did not form a urethral stricture, was 37,5% (n=13) and in the group with urethral strictures - 60,6% (n=20). Having chronic inflammation, which was confirmed upon subsequent morphologic examination of prostate tissue resection, were detected in the first group at 32,5% (n=13) patients and in the group number 2 at 66,6% (n=22) patients and was significantly higher in the second group (p<0,05). Conclusions: The duration of TURP more than 60 minutes, prostate volume of more than 70 cm3, the presence of diabetes mellitus, and also chronic inflammation of the prostate significantly increases the risk of urethral stricture in the late postoperative period.

Stricture, Urethra, Benign Prostatic Hyperplasia (BPH), Transurethral Resection of the Prostate (TURP)