DIAGNOSIS OF METABOLIC DISORDERS AND METAPHYLAXIS OF RECURRENT CALCIUM OXALATE UROLITHIASIS
- Authors: Kustov A.V1,2, Strelnikov A.I2, Airapetyan A.O2, Moryganov M.A3, Zhuravleva N.I4
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Affiliations:
- FSBIS ISC n.a. G.A. Krestov RAS
- SBEI HPE IvSMA of RMPH
- Urological Unit of the Ivanovo Regional Clinical Hospital
- LLC "Impact
- Issue: No 5 (2015)
- Pages: 86-88
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/282275
- ID: 282275
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Abstract
The paper presents the results of the 1-year screening of biochemical parameters of urine in female patient with recurrent calcium urate urolithiasis. Based on the data of quantitative X-ray phase analysis of the composition of stone and a complex of clinical and laboratory examination, reasons for recurrent stone formation were determined. The main reasons included hypocitraturia, hyperosmolarity of urine and uric acid diathesis. Therapy with citrate mixtures and adequate water schedule (daily urine - 2-2.5 liters) for 10 weeks allowed to increase the urinary pH, led to 2.5-fold increase in daily urinary citrate excretion and getting rid of residual stones in both kidneys. The effect of citrate therapy lasted for a further six months after drug withdrawal. Subsequently, the daily urinary citrate excretion and pH decreased, but even after 8 months remained still above baseline values. Obviously, for high risk patients it is necessary to define the daily excretion of citrate, and diagnosis of hypocitraturia requires long course therapy with citrate mixtures, with a break of not more than six months and obligate maintenance of adequate diuresis.
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About the authors
A. V Kustov
FSBIS ISC n.a. G.A. Krestov RAS; SBEI HPE IvSMA of RMPH
Email: kustov@isuct.ru
Doctor of Chemical Sciences, Leading Researcher
A. I Strelnikov
SBEI HPE IvSMA of RMPHDepartment of Faculty Surgery and Urology
A. O Airapetyan
SBEI HPE IvSMA of RMPHDepartment of Faculty Surgery and Urology
M. A Moryganov
Urological Unit of the Ivanovo Regional Clinical Hospital
N. I Zhuravleva
LLC "Impact
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