Periprostatic inflammation as a risk factor for the development of vesico-urethral stenosis after radical prostatectomy


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Abstract

This article presents results of a study conducted to identify the causes of stenosis in the region of vesico-urethral anastomosis (VUA) after radical prostatectomy (RP). Tissue specimens from removed prostates were evaluated in 115 prostate cancer patients with a favorable postoperative period (group 1) and 5 patients who develop VUA stenosis between 6 months to1 year after RP. It was found that in the group 1 inflammatory infiltration did not basically affect tumor growth zones, was mild and did not spread beyond the prostate. Patients of the group 2 had maximum inflammation, with the inflammatory infiltration localized in the prostate regions, both affected and not affected by the tumor, and periprostatically. Taking into account more severe inflammatory response in the prostate with extracapsular extension of the process and the involvement of periprostatic structures in patients who developed VUA stenosis after RP, compared to those without VUA stenosis, we can consider this phenomenon as a risk factor for stenotic complications in the vesico-urethral segment after RP.

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About the authors

M. B Chibichyan

Institute of Arid Zones of Southern Scientific Center of RAS; Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia

Email: michel_dept@mail.ru
Ph.D., Associate Professor at Department of Urology and Human Reproductive Health with Course of Pediatric Urology-Andrology

M. I Kogan

Institute of Arid Zones of Southern Scientific Center of RAS; Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia

T. O Lapteva

Regional Consultative and Diagnostic Centre

I. I Belousov

Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia

A. G Ivanov

Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia

E. A Chernogubova

Institute of Arid Zones of Southern Scientific Center of RAS

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