MICRORNAS AS POTENTIAL NONINVASIVE MARKERS IN THE DIAGNOSIS OF UROLOGICAL MALIGNANCIES


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Abstract

Small non-coding RNAs (microRNAs) are involved in almost all biological mechanisms of carcinogenesis. Due to their stability in biological fluids microRNAs may serve a perspective biomarker for diagnosis and prognosis of oncological diseases. The review is dedicated to the analysis of microRNAs, as potential diagnostic markers of urological malignancies. Recent advances in the knowledge of miRNAs origin in body fluids, their stability and application as a potentially new class of biomarkers in medicine are summarized and discussed in the article.

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About the authors

I. R Gilyazova

Email: gilyasova_irina@mail.ru
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences PhD (Biol.Sci.), Research Fellow at the Laboratory of Molecular Human Genetics

E. A Klimentova

Email: lissa987@yandex.ru
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences

V. N Pavlov

Email: rectorat@bgmy.ru
Bashkir State Medical University, Department of Urology Ufa

E. K Khusnutdinova

Email: ekkh@anrb.ru
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences Bashkir State University, Department of Genetics and Fundamental Medicine

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