FIVE-YEAR ANALYSIS OF MICROBIAL LANDSCAPE OF TRANSPLANTATION AND DIALYSIS CENTER (2011-2015)

Introduction. Treatment of bacterial infections is pressing and difficult task of modern transplantology. Aim. To analyze the spectrum of bacterial microflora and bacterial sensitivity to antibiotics in patients of the transplantation and dialysis center. Results. The study analyzed the results of bacteriological tests performed in 534 patients with chronic kidney disease stage 5 in 2011- 2015. Biomaterials for the examination included urine, blood, wound discharge and sputum. Gram-positive bacteria, Gram-negative bacteria, fungi and mixed flora were found in 42%, 39%, 4% and 15%, respectively. Among observed associations 51% were presented by a combination of Gram-positive and Gram-negative bacteria and the others were different combinations offungi. The most often detected bacteria were Enterococcus spp. (37%), Klebsiella pneumoniae (25%), Staphylococcus spp. (19%), E. coli (13%), Streptococcus spp. (6%), P. aeruginosa (5%). Fungi of the genus Candida were isolated from 11% of all cultures. Enterococci and Klebsiella had pronounced resistance to most antibiotics. All grampositive bacteria were highly sensitive to vancomycin and linezolid. Discussion. The findings suggest that the percentage of Gram-negative bacteria that are resistant to antibiotics is increasing. Conclusion. Significant changes in the microbial landscape and the growing antibiotic resistance dictate the need for periodic analysis of the bacterial flora in the transplantation and dialysis center.

chronic kidney disease, bacteria, infection, antibiotic resistance, bacterial flora