PROSPECTS FOR USING BIOLOGICAL MARKERS IN VARIOUS TYPES OF URINARY STONE LITHOTRIPSY
- Authors: Kutluev M.M1, Pulin I.L1, Ryakhov A.Y.1, Mochalov K.S2, Farkhutdinov R.R2
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Affiliations:
- Multidisciplinary Medical Medical Clinic «Medservice»
- Bashkir State Medical University
- Issue: No 6 (2016)
- Pages: 11-16
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/286566
- ID: 286566
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Abstract
Aim. To investigate the feasibility of using biological markers for determining the optimal timing to repeat lithotripsy of urinary stones. Materials and methods. This was a prospective, randomized, singlecenter cohort study of 100 patients randomized into 4 groups. Patients of group I (n=46), II (n=20), III (n=18) and IV (n=16) were used contact lithotripsy (URS), ESWL, PNL, combined lithotripsy. In all patients, before surgery and at 1, 7, 14, 20 days after lithotripsy, iron-induced urine chemiluminescence was measured to determine the level of reactive oxygen species (ROS) and concentration of medium-mass molecules (MMM) in urine. Results. Analyzing the time of operation and the size of stones only in group I was detected the significant negative correlation (r=-0,479, p<0,05). In patients of all groups, the level of ROS have decreased after the surgery with further returning to baseline level. Dynamics of changes MMM in urine has not revealed a reliable change tendency. Conclusion. The definition of the quantity of ROS in urine is a promising criterion in measuring the degree of urinary system damage and the time for repeated lithotripsy. The level of ROS in the urine after URS, ESWL and the ESWL-URS combination returns to baseline on the 7th day and after PNL on the 14th day postoperatively, thus allowing to pathogenetically define the optimal timing of repeat lithotripsy.
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About the authors
M. M Kutluev
Multidisciplinary Medical Medical Clinic «Medservice»
Email: marrat@rambler.ru
PhD, Urologist at the Department of Urology
I. L Pulin
Multidisciplinary Medical Medical Clinic «Medservice»
Email: ivan.pulin@mail.ru
A. Ya Ryakhov
Multidisciplinary Medical Medical Clinic «Medservice»
Email: snosdlt@yandex.ru
K. S Mochalov
Bashkir State Medical University
Email: kostja.mochalov@yandex.ru
R. R Farkhutdinov
Bashkir State Medical University
Email: farkhutdinov@mail.ru
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