Diagnostic and prognostic significance of urinary microvesicles


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Abstract

In recent years, researchers have become increasingly interested in urinary microvesicles. They contain disease-specific biomarkers and can be used for predicting and diagnosing various diseases of the urinary system without resorting to invasive procedures. This review presents data on domestic and international research investigating the importance and potential application of urinary microvesicles for the diagnosis and prediction of diseases of the urinary system.

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About the authors

E. G Baksheeva

Chita State Medical Academy of Minzdrav of Russia

Email: elena.baksheeva.94@mail.ru
Ph.D. Student at the Department of Pathological Physiology

N. N Tsybikov

Chita State Medical Academy of Minzdrav of Russia

Email: thybikov@mail.ru
Dr.Med.Sci., Professor at the Department of Pathological Physiology.

References

  1. Février B., Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Current opinion in cell biology. 2004;16(4):415-421. doi: 10.1016/j.ceb.2004.06.003. PMID: 15261674.
  2. Salih M., Zietse R., Hoorn E.J. Urinary extracellular vesicles and the kidney: biomarkers and beyond. Am J Physiol Renal Physiol. 2014;306:1251-1259.
  3. Pisitkun T., Shen R.F., Knepper M.A. Identification and proteomic profiling of exosomes in human urine. ProcNatlAcadSci USA. 2004;101:13368-13373.
  4. Gonzales P.A., Pisitkun T., Hoffert J.D., Tchapyjnikov D., Star R.A., Kleta R., Wang N.S., Knepper M.A. Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am SocNephrol. 2009;20:363-379.
  5. Zhou H., Cheruvanky A., Hu X., Matsumoto T., Hiramatsu N., Cho M.E., Berger A., Leelahavanichkul A., Doi K., Chawla L.S., Illei G.G., Kopp J.B., Balow J.E., Austin H.A. 3rd, Yuen P.S., Star R.A. Urinary exosomal transcription factors, a new class of biomarkers for renal disease. Kidney Int. 2008;74:613-621.
  6. Kalani A., Mohan A., Godbole M.M., Bhatia E., Gupta A., Sharma R.K., Tiwari S. Wilm’s tumor-1 protein levels in urinary exosomes from diabetic patients with or without proteinuria. PLoS One. 2013;8:e60177.
  7. Zhou H., Kajiyama H., Tsuji T., Hu X., Leelahavanichkul A., Vento S., Frank R., Kopp J.B., Trachtman H., Star R.A., Yuen P.S. Urinary exosomal Wilms’ tumor-1 as a potential biomarker for podocyte injury. Am J Physiol Renal Physiol. 2013;305:553-559.
  8. Hara M., Yanagihara T., Kihara I., Higashi K., Fujimoto K., Kajita T. Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury. J Am SocNephrol. 2005;16:408-416.
  9. Hara M., Yanagihara T., Hirayama Y., Ogasawara S., Kurosawa H., Sekine S., Kihara I. Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli. Hum Pathol. 2010;41:1265-1275.
  10. Samsonov R., Shtam T., Burdakov V., Glotov A., Tsyrlina E., Berstein L., Nosov A., Evtushenko V., Filatov M., Malek A. Lectin-induced agglutination method of urinary exosomes isolation followed by mi-RNA analysis: Application for prostate cancer diagnostic. Prostate. 2016;76(1):68-79.
  11. Lv L.L., Cao Y.H., Ni H.F., Xu M., Liu D., Liu H., Chen P.S., Liu B.C. MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis. Am J Physiol Renal Physiol. 2013;305:1220-1227.
  12. Малов В.И. Клинические варианты поражения почек при сахарном диабете. Забайкальский медицинский вестник. 2017;1:616.379-008.6:616.61:137.
  13. Rossi L., Nicoletti M.C., Carmosino M., Mastrofrancesco L., Di Franco A., Indrio F., Lella R., Laviola L., Giorgino F., Svelto M., Gesualdo L., Procino G. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. J Diabetes Res. 2017:4360357.
  14. Mitchell P.J., Welton J., Staffurth J., Court J, Mason M.D., Tabi Z., Clayton A. Can urinary exosomes act as treatment response markers in prostate cancer? J Transl Med. 2009;7(1):4.10.1186/1479-5876-7-4.
  15. Bijnsdorp I.V., Geldof A.A., Lavaei M., Piersma S.R., van Moorselaar R.J., Jimenez C.R. Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. J Extracell Vesicles. 2013;2:22097.10.3402/jev.v2i0.22097.
  16. Raimondo F., Morosi L., Corbetta S., Chinello C., Brambilla P., Della Mina P., Villa A., Albo G., Battaglia C., Bosari S., Magni F., Pitto M. Differential protein profiling of renal cell carcinoma urinary exosomes. MolBiosyst. 2013;9(6):1220.10.1039/c3mb25582d.

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