Prospects of using bacteriophages in urological practice


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Abstract

In modern clinical practice, antimicrobial resistance creates a significant problem for the effective metaphylaxis of various infectious and inflammatory diseases of the urinary system. Annually, researchers note an increasing number of mutations in the genomes of bacteria that cause infectious diseases, which leads to the appearance of more aggressive strains. The inefficiency of antibiotic therapy requires to a search for alternative methods for treatment and prevention of infectious diseases. use of viruses that infect bacteria (bacteriophages) represent one of such methods. A literature review of recent publications indicates that phage therapy has been gained significant increase. The general aspects of phage therapy, mechanism of action, as well as the existing possibilities and limitations of phage therapy in treatment and prevention of infectious diseases of the urinary system are highlighted in this article.

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About the authors

A. A Shiryaev

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: phd.shiryaev@gmail.com
Department of Urology Resident Moscow, Russia

A. O Vasilyev

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: alexvasilyev@me.com
PhD, Teaching Assistant at the Department of Urology Moscow, Russia

A. V Zaitsev

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: zaitcevandrew@mail.ru
Dr.Med.Sci., Prof, at the Department of Urology Moscow, Russia

E. A Prilepskaya

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: prilepskayae@mail.ru
Department of Urology Senior Laboratory Assistant Moscow, Russia

N. A. Sazonova

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Department of Urology Resident Moscow, Russia

I. E Grigoryan

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

student Moscow, Russia

Yu. A Kim

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: dockimyura@gmail.com
Department of Urology Resident Moscow, Russia

D. Yu Pushkar

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Email: pushkardm@mail.ru
academician of RAS, Dr.Med.Sci., Prof., Head of the Department of Urology Moscow, Russia

References

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  16. Vasilyev A.O., Zaitsev A.V., Kalinina N.A., Shiryaev A.A., Kim Yu.A., Pushkar D.Yu. Bacteriophages in the treatment of lower urinary tract infections. Consilium Medicum. 2019;21(7) :38-41. Russian (Васильев А.О., Зайцев А.В., Калинина Н.А., Ширяев А.А., Ким Ю.А., Пушкарь Д.Ю. Бактериофаги в лечении инфекций нижних мочевыводящих путей. Consilium Medicum. 2019;21(7):38-41).
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