Efficiency and safety of phenazopyridine for treatment of uncomplicated urinary tract infection: results of multi-center, randomized, placebo-controlled, clinical study
- Authors: Petrov S.B.1, Slesarevskaya M.N1, Chibirov K.H2, Topuzov M.E3, Kagan O.F4, Voronova E.N5
-
Affiliations:
- Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
- FGBOU Saint Petersburg Scientific and Research Institute of Phthisiopulmonology of Ministry of Health of Russia (Department of phthisionephrology and urology)
- North-Western State Medical University n.a. I.I. Mechnikov
- Ltd MedEsteticCenter Laboratory
- Ltd Avrora Medi
- Issue: No 3 (2020)
- Pages: 15-21
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/312454
- DOI: https://doi.org/10.18565/urology.2020.3.15-21
- ID: 312454
Cite item
Abstract
Full Text
About the authors
S. B. Petrov
Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
Email: petrov-uro@yandex.ru
Dr.Med.Sci., professor, Head of the Scientific and Research Center of Urology. Scientific and Research Institute for Surgery and Emergency Medicine of Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia Saint Petersburg, Russia
M. N Slesarevskaya
Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
Email: mns-1971@yandex.ru
M.N. - Ph.D., senior researcher at Scientific and Research Center of Urology in Scientific and Research Institute for Surgery and Emergency Medicine of Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia Saint Petersburg, Russia
K. H Chibirov
FGBOU Saint Petersburg Scientific and Research Institute of Phthisiopulmonology of Ministry of Health of Russia (Department of phthisionephrology and urology)
Email: ckk_mma@mail.ru
urologist, Department of Phthisionephrology and urology, FGBOU Saint Petersburg Scientific and Research Institute of Phthisiopulmonology of Ministry of Health of Russia Saint Petersburg, Russia
M. E Topuzov
North-Western State Medical University n.a. I.I. Mechnikov
Email: martop@mail.ru
Dr.Med.Sci, MD, professor at the Department of Urology, North-Western State Medical University n.a. I.I. Mechnikov Saint Petersburg, Russia
O. F Kagan
Ltd MedEsteticCenter Laboratory
Email: ofkagan@mail.ru
Dr.Med.Sci, MD, Ltd MedEsteticCenter Laboratory Saint Petersburg, Russia
E. N Voronova
Ltd Avrora Medi
Email: Nickolaevna@mail.ru
urologist at the Ltd Avrora Medi Saint Petersburg, Russia
References
- Foxman B., Brown P. Epidemiology of urinary tract infections: Transmission and risk factors, incidence, and costs. Infect. Dis. Clin. N. Am. 2003;17:227-241. doi: 10.1016/s0891-5520(03)00005-9
- Ronald A.R., Nicolle L.E., Stamm E., Krieger J., Warren J., Schaeffer A., Naber K.G., Hooton T.M., Johnson J., Chambers S. et al. Urinary tract infection in adults: Research priorities and strategies. Int. J. Antimicrob. Agents 2001;17:343-348. doi: 10.1016/s0924-8579(01)00303-x
- Bonkat G., Pickard R., Bartolett R. et al. Urological Infections EAU Guidelines, 2020. http://uroweb.org/guideline/urological-infections
- Naber K.G., Cho Y.H., Matsumoto T., Schaeffer A.J. Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis. Int. J. Antimicrob. Agents. 2009;33(2):111-119.
- Yang H.J., Kim Y.H., Kim M.E. A Preliminary Study of Troublesome Symptoms in Women with Acute Uncomplicated Cystitis Korean J urol. 2007;48:1082-1087.
- Кузьмин И.В., Аль-Шукри С.Х., Слесаревская М.Н. Лечение и профилактика рецидивирующей инфекции нижних мочевых путей у женщин. Урологические ведомости. 2019;9(2):5-10). Doi: 10.17816/ uroved925-10.
- Борисов В.В. Диагностика и терапия инфекций мочевыводящих путей. О чем следует помнить всегда (клиническая лекция). Часть 1. Урологические ведомости. 2017;7(3):52-59. doi: 10.17816/uroved7352-59.
- Аль-Шукри С.Х., Слесаревская М.Н., Кузьмин И.В. Применение фосфомицина при лечении неосложненной инфекции нижних мочевыводящих путей. Урология. 2018;5:153-159.
- Перепанова Т.С., Козлов Р.С. и др. Антимикробная терапия и профилактика инфекций почек, мочевыводящих путей и мужских половых органов. Федеральные клинические рекомендации. М., 2020. 110 с.
- Страчунский Л.С. Норфлоксацин (Ноцилин) в лечении инфекций мочевыводящих путей / Материалы международного симпозиума: «Инфекции мочевыводящих путей у амбулаторных больных» 16 февраля 1999 г. М., 1999. Р. 29-32.
- Амдий Р.Э., Аль-Шукри С.Х., Кузьмин И.В., Сорокин Н.В., Чаплицкий Е.А., Скворцов М.В., Алексеев А.С., Окунчаев А.Ш., Турбин А.А., Тимаева Г.Р., Булаев Д.В., Москалева Ю.С. Опыт применения канефрона при лечении острого неосложненного цистита у женщин Урологические ведомости. 2016;6(2):16-22.
- Kyungtae Ko, Won Ki Lee, Cheol Young Oh et al. Is A Combination of Antibiotics and Non-Steroidal Anti-Inflammatory Drugs More Beneficial Than Antibiotic Monotherapy For The Treatment of Female Acute Uncomplicated Cystitis? A Randomized Controlled Pilot Study. Female Urology. 2018;15(06):365-369. doi: 10.22037/uj.v0i0.3716.
- Sri Sivalingam, Manoj Monga. Management of Ureteral Stent Discomfort in Contemporary Urology Practice. Urology Practice 1. 2014:141-145. doi: 10.1016/j.urpr.2014.06.001.
- Thomas B.H., Whitehouse L.W., Solomonraj G., Paul C.J. Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice and guinea pigs. J Pharm Sci 1990;79(4):321-325.
- Wander H.J., Pascoe D.J. Phenylazopyridine hydrochloride poisoning. Report of case and review of literature. Am. J. Dis. Child. 1965;110:105-107.
- Pergialiotis V., Arnos P.,Mavros M.N.,Pitsouni E.,Athanasiou S.,Falagas M.E. Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? Expert Rev Anti Infect Ther. 2012;10(8):875-879. doi: 10.1586/eri.12.72.
- Aizawa N., Wyndaele J.J. Effects ofphenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen. Neurofuran Urodyn. 2010;29(8):1445-1450. doi: 10.1002/nau.20886.
- Trickett P.C. Ancillary use of phenazopyridine (Pyridium) in urinary tract infections. Curr. Ther. Res. Clin. Exp. 1970;12(7):441-445.
- Anderson C., Chimhanda M., Sloan J., Galloway S., Sinacore J., Brubaker L. Phenazopyridine does not improve catheter discomfort following gynecologic surgery. Am. J. Obstet. Gynecol. 2011; 204(3):267.e1-267.e3.
- Gilderman L., Hendry D., Patrick K. Evaluation of the efficacy of phenazopyridine Hydrochloride (Formula PD-F-0016) as a urinary analgesic in women with urinary tract infections. FDA’s Dockets Management. Protocol Number: 99-001-P (2001).
- Deepalatha C., Deshpande N. A comparative study of phenazopyridine (pyridium) and cystone as short-term analgesic in uncomplicated urinary tract infection. Int J Pharm Sci 2011;3(Suppl. 2):224-226.
- Pyridium drug description. Available at: www.rxlist.com
- Shireen N. Farzadeh, Emily M. Ambizas Urinary Tract Infections and Self-Care Options. Infectious disease 15, 2017 https://www. uspharmacist.com/article/urinary-tract-infections-and-selfcare-options
- Винаров А.З., Спивак Л.Г. Современные возможности симптоматической терапии дизурии. Урология. 2019;2:97-102. https://dx.doi.org/10.18565/urology.2019.2.97-102.
- Duenas-Garcia O.F., Sierra T., Taylor D., Leung K., Hall C.D., Flynn M.K. The Effect of Oral Phenazopyridine on Perioperative Voiding After Midurethral Slings (EPIPhANy Study). Female Pelvic Med Reconstr Surg. 2018;24(2):95-99. doi: 10.1097/SPV.0000000000000497.
- Norris R.D., Sur R.L., Springhart W.P., Marguet C.G., Mathias B.J., Pietrow P.K., Albala D.M., Preminger G.M. A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus for the management of postoperative ureteral stent discomfort. Urology. 2008;71(5):792-795.
- Рафальский В.В., Моисеева Е.М. Эпидемиология неосложненных внебольничных инфекций мочевыводящих путей в Российской Федерации. Вестник урологии. 2018;6(2):30-37. doi: 10.21886/2308-6424- 2018-6-2-30-37