Renomedullary interstitial cell tumor: review of a rare clinical case


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Abstract

Autopsy study of a 49-year-old patient demonstrates a rare kidney tumor that had a structure of a mesenchymal renomedullary interstitial tumor (RIO), which had specific characteristics. They include a predominance of the cellular component in the tumor, represented by cells with processes elements (fibroblasts, myofibroblasts), which were surrounded by collagen fibers of interstitium. Apparently, these cells can be involved in the regulation of renin and bicarbonates, the exchange of components of connective tissue (collagen fibers, proteoglycans) and hormones (estrogen, progesterone). Since these tumor cells regulate the synthesis and secretion of the substances, numerous clinical manifestations of RIO can be explained. Most likely, these include increased blood pressure, water-electrolyte disorders, hormonal disorders due to the presence of estrogen receptors, progesterone in the tumor tissue and metabolic disorders (diabetes mellitus). However, these assumptions require further clinical, morphological and immunohistochemical studies.

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About the authors

S. S Todorov

Rostov State Medical University

Email: sertodorov@gmail.com
MD, pathologist of the Highest Category; Head of the Morphological Department of the Clinic Rostov-on-Don, Russia

M. I Kogan

Rostov State Medical University

Honored Scientist of the Russian Federation, MD, professor; Head of the Department of Urology and Reproductive Health with a Course of Pediatric Urology and Andrology, Faculty of the advanced training and professional retraining of specialists Rostov-on-Don, Russia

V. Yu Deribas

Rostov State Medical University

Pathologist of the Highest Category, Morphological Department of the Clinic of Rostov State Medical University; assistant at the Department of Pathological Anatomy Rostov-on-Don, Russia

A. S Kazmin

Rostov State Medical University

Pathologist at the Morphological Department of the Clinic of Rostov State Medical University; assistant at the Department of Pathological Anatomy Rostov-on-Don, Russia

References

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