Long-term results of radical surgery treatment of patients with bladder cancer


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Abstract

Purpose. To investigate long-term results after radical cystectomy in patients with bladder cancer. Materials and methods. Since 1997 to 2020 yy. we have performed 404 radical cystectomy with different methods of derivation for patients with bladder cancer in our clinic. There were 342 (86,4%) men and 62 (13,6%) women. Laboratory study, ultrasound, X-ray, CT. MRI investigations were performed in all patients. Results. Mortality rate was 2,9%. Early and late postoperative complications have occurred in 136 (33,6%) and 98 (41,8%) cases, respectively. Local recurrence has occurred in 33 (8,5%) patients. 10-years overall and cancer-specific survival were 43,4% and 47,2%, respectively. In lymph-negative patients 2-years and 5-years overall survival were 81,2% and 67,2%, respectively. In lymph positive patients 2-years and 5-years overall survival were 46,9% and 13,9%, respectively. In lymph-negative patients 2-years and 5-years cancer-specific survival were 83,6% and 70,7%, respectively. In lymph positive patients 2-years and 5-years cancer-specific survival were 51,0% and 15,1%, respectively. Overall and cancer -specific survival decreased according to increasing pT-stage and histopathologic grade. Conclusions: pT-stage (pT), lymp nodes status (pN), histopathologic grade ( pG) have a significant independent influence on overall and cancer-specific survival of bladder cancer patients after radical cystectomy.

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About the authors

B. K Komyakov

Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”; Multiprofile city hospital#2

Email: komyakovbk@mail.ru
Dr. Med.Sci., professor, Сhief of the department of urology

A. V Sergeev

Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”; Multiprofile city hospital#2

Email: urolsergeev@gmail.com
Dr. Med. Sci., professor of department of urology

V. A Fadeev

Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”; Multiprofile city hospital#2

Email: fad_ur_75@mail.ru
Dr. Med. Sci., professor of department of urology

T. H Al-Attar

Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”; Multiprofile city hospital#2

Email: dr-talat@mail.ru
Cand. Med. Sci., assistant at the department of urology

E. O Stetsik

Multiprofile city hospital#2

urologist

A. Y Ulyanov

Multiprofile city hospital#2

Email: doctor-drun.0704@yandex.ru
urologist

Y. S Savashinsky

Multiprofile city hospital#2

Email: jar4ik@mail.ru
urologist

O. A Kirichenko

Multiprofile city hospital#2

Email: oa.kir@yandex.ru
urologist

L. M Rodygin

Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”

Email: rodyginlm@mail.ru
Cand. Med. Sci., docent at the department of urology

References

  1. Hautmann R.E., dePetriconi R.C., Volkmer B.G. 25 Years of experience with 1 000 neobladders: long-term complications. J. Urol 2011; 185: 2207-2212.
  2. Morgan T.M., Kaffenberger S.D., Cookson M.S. Surgical and chemotherapeutic management of regional lymph nodes in bladder cancer. J. Urol 2012; 188:1081-1088.
  3. Chen J., Zhang H., Sun G. et al. Comparison of the prognosis of primary and progressive muscle-invasive bladder cancer after radical cystectomy: A systemic review and meta-analysis. Int.Journal of Surgery 2018; 52: 214-220.
  4. Faba O.R., Tyson M.D., Artibani W. et al. Update of the ICUD-SIU International Consultation on Bladder Cancer 2018: Urinary Diversion. World Journal of Urol. 2019; 37: Iss. 1; 85-93.
  5. Комяков Б.К., Гулиев Б.Г., Сергеев А.В. и соавт. Оперативное лечение уролитиаза у больных после радикальной цистэктомии с кишечной пластикой. Экспериментальная и клиническая урология. 2015;3:68-71
  6. Eisenberg M.S., Boorjian S.A., Cheville J.C. et al. The SPARC score: a multifactorial outcome prediction model for patients undergoing radical cystectomy for bladder cancer. J. Urol 2013;190: 2005-2010.
  7. Merseburger A.S., Apolo A.B., Chowdhury S. et al. SIU-ICUD recommendations on bladder cancer: systemic therapy for metastatic bladder cancer. World Journal of Urol. 2019;37:Iss. 1; 95-105.
  8. Комяков Б.К., Сергеев А.В., Фадеев В.А. Лимфодиссекция при радикальной цистэктомии. Вопросы онкологии. 2010;56 (5): 508-513
  9. Комяков Б.К., Гулиев Б.Г., Сергеев А.В. и соавт. Выживаемость больных раком мочевого пузыря после радикальной цистэктомии. Онкоурология. 2016;1(12):40-46
  10. Красный С.А., Суконко О.Г., Ролевич А.И. Результаты лечения больных раком мочевого пузыря с метастазами в регионарных лимфоузлах. Онкоурология. 2007;3:35-41
  11. Хабалов Р.В., Матвеев Б.В., Волкова М.И., Носов Д.А. Лечение и прогноз больных переходно-клеточным раком мочевого пузыря с метастазами в регионарные лимфоузлы. Онкоурология. 2007;4:30-35
  12. Tilki D., Svatek R.S., Novara G. et al. Stage pT0 at radical cystectomy confers improved survival: an international study of 4,430 patients. J. Urol 2010;184:888-894.
  13. Abol-Enein H., Tilki D., Mosbah A. et al. Does the extent of lymphadenectomy in radical cystectomy for bladder cancer influence disease-free survival? A prospective single-center study. Eur Urol 2011;60:572- 77.
  14. May M., Herrmann E., Bolenz C. et al. Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy. Eur Urol 2011;59:712-718.
  15. Комяков Б.К., Сергеев А.В., Фадеев В.А. и соавт. Сопутствующие онкопатологические изменения в предстательной железе больных раком мочевого пузыря после радикальной цистпростатэктомии. Урология. 2017;4:42-45
  16. Faba O. R., Palou J., Rosales A. et al. Clinical predictive factors of poor outcome in patients with stage pT0 disease at radical cystectomy. J. Urol 2011;186:442-447.
  17. Ghoneim M.A., Abdel Latif M., El-Mekresh M. et al. Radical cystectomy for carcinoma of the bladder: 2 720 consecutive cases 5 years later. J. Urol 2008;180:121-127.

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