Experimental study on the efficiency of rectal suppositories with oxidized dextran in patients with benign prostatic hyperplasia


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详细

Aim: to evaluate therapeutic activity of oxidized dextran after rectal administration in a modified sulpiride model ofbenign prostatic hyperplasia in mice. Materials and methods: The therapeutic activity of oxidized dextran was studied in an experimental model of benign prostatic hyperplasia in mice (sulpiride model). All in vivo studies were carried out on 30 male BALB/c mice with an average body weight of 30-35 g. Results: It was found that rectal administration of a solution of oxidized dextran effectively neutralizes pathomorphological changes in experimental model of benign prostatic hyperplasia. In the group of animals, which received 2% solution of oxidized dextran as treatment, the most prominent therapeutic effect in an experimental model was seen and it was confirmed by a decrease in the bladder detrusor thickness and the normalization of its lumen.

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作者简介

E. Novikova

Federal State Budget Scientific Institution “Federal Research Center of Fundamental and Translational Medicine”; Regional Medical and Diagnostic Centre Ltd

Email: rmdc.nsk@gmail.com
Ph.D., Senior Researcher of Endocrinology Laboratory of Federal Research Center of Fundamental and Translational Medicine; urologist and andrologist

A. Troitsky

Federal State Budget Scientific Institution “Federal Research Center of Fundamental and Translational Medicine”

Email: pharm2008@yandex.ru
Ph.D., leading researcher, Head of the Laboratory for biocompatible nanoparticles, nanomaterials and targeted delivery systems

H. Ukah

Federal State Budget Scientific Institution “Federal Research Center of Fundamental and Translational Medicine”

Email: dukehenry@mail.ru
researcher of Laboratory for biocompatible nanoparticles, nanomaterials and targeted delivery systems

V. Selyatitskaya

Federal State Budget Scientific Institution “Federal Research Center of Fundamental and Translational Medicine”

Email: ccem@centercem.ru
doctor of biological sciences, professor, Chief Researcher of Endocrinology Laboratory

参考

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  2. Potapova O.V., Sharkova T.V., Cherdantseva L.A., Shkurupy V.A., Kovner A.V., Troitskii AV, Shestopalov AM. Preventive effects of oxidized dextran on functional activity of pulmonary macrophages in mice infected with influenza A virus. Bulletin of Experimental Biology and Medicine. 2018;165(1):57-60.
  3. Ткачев В.О., Колесникова О.П., Троицкий А.В., Шкурупий В.А. Влияние окисленных декстранов на NO-синтазную и аргиназную активность макрофагов мышей Бюллетень экспериментальной биологии и медицины. 2008;146(7):91-93
  4. Потапова О.В., Шкурупий В.А., Шаркова Т.В., Троицкий А.В., Лузгина Н.Г., Шестопалов А.М. Исследование профилактической эффективности окисленного декстрана и патоморфологических процессов в легких мышей при гриппе птиц A/H5N1. Бюллетень экспериментальной биологии и медицины. 2010;150(12):650-653
  5. Тишевская Н.В., Максаков Д.А., Головнева Е.С. Морфологические особенности сульпиридной модели доброкачественной гиперплазии предстательной железы у крыс. Экспериментальная и клиническая урология. 2017;2:16-19

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