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No 5 (2021)


Serum testosterone and testicular hemodynamics before and after infection with SARS-COV-2 (pilot study)

Ibishev K.S., Mamedov E.A., Gusova Z.R., Palenyy A.I., Prokop Y.O.


Introduction. The current epidemiological situation dictates a detailed study ofthe effect ofa new coronavirus infection (SARS-CoV-2) on various anatomical, histological, physiological and biochemical parameters of the human body, which has become an integral part of many medical research, including urology, andrology, endocrinology. Objective. To study serum testosterone levels and testicular hemodynamics before and after infection with SARS-CoV-2. Materials and methods. 20 patients were examined, before and after suffering SARS-CoV-2 infection (who fell ill at the beginning of 2020). Average age 37.8 years (min=27, max=50). The level of total testosterone (Is) in the blood serum and hemodynamic parameters of the testicles (maximum and minimum blood flow velocity and resistance index) were studied. Results: When studying the level of !s 3 months after the transferred SARS-CoV-2, its decrease from the initial value was noted (r=0.47; p=0.35), and after 6 months (r=0.98; p<0.007) there was no recovery of the target level of Ts before infection with SARS-CoV-2. Regarding the hemodynamics of the testicles, there was also a decrease in Vmax and Vmin, and an increase in RI, which indicates a deterioration in the blood flow of the testicles (p<0.001). Conclusion: SARS-CoV-2 affects the level of Ts in the blood serum and the parameters of the hemodynamics of the testicles. The extent to which SARS-CoV-2 affects patient performance depends largely on the severity of the disease and to a lesser extent on baseline performance.
Urologiia. 2021;(5):5-9
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Involvement of p2 receptors in the contractile activity of the bladder in patients with benign prostatic hyperplasia

Ziganshin A.U., Ivanova D.V., Zubkov E.A., Sitdykova M.E.


Aim: to study the role of P2 receptors in impaired bladder contractility in patients with lower urinary tract obstruction. Materials and methods: in pharmacological studies, tissue samples from the bladder wall of 30 patients were used, obtained during planned surgical interventions for benign prostatic hyperplasia (transvesical simple prostatectomy without placement of cystostomy tube). Based on these tissue, isolated smooth muscle specimens were prepared. Their mechanical activity and the efficiency of ligands of purine P2 and other receptors were evaluated. With this aim, the following P2-receptor agonists were used: adenosine triphosphoric acid (ATP), adenosine diphosphoric acid (ADP), uridine-5'-triphosphoric acid (UTP), alpha, beta-methylene-ATP, 2-methylthio-ADP, as well as antagonists of P2-disulfonate receptors acid (PPADS), suramin, NF023, MRS2500. In addition, the efficiency of ligands of other receptors, including carbacholine, epinephrine, histamine, serotonin, atropine was evaluated. Results: the most effective agonist was alpha-beta-methylene-ATP, while ATP and 2-methylthio-ADP were significantly less active. In our experiments, ADP and UTP did not show an effect on human bladder. The influence of P2 receptor agonists was inhibited by P2 receptor antagonists PPADS and suramin, as well as MRS2500, although to a lesser extent. Carbacholine caused a strong concentration-dependent contractile response of the bladder, which was inhibited by atropine. Histamine resulted in mild bladder contractions only at high concentrations. Epinephrine and serotonin did not cause significant changes in the contractile activity of the bladder. Conclusion: The main subtype of P2 receptors involved in the contractile activity of the human bladder is P2X1 receptors. P2Y1 receptors also have some influence on the contraction, while other subtypes of P2 receptors are not detected by pharmacological methods.
Urologiia. 2021;(5):10-14
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Road combined trauma of the urinary system organs: organization and clinical tactics in a multidisciplinary hospital

Esipov A.V., Kochetov A.G., Alekhnovich A.V., Fokin Y.N., Gvasalia B.R., Grizkevich A.A., Esipov A.S., Karabach I.V.


Introduction. Damage to the organs of the urinary system (UMS) in road trauma (DT) is 4%, of which multiple and combined - over 70%. The aim of the study is to determine the main organizational and clinical directions for improving the EMC in case of trauma OMS in a trauma center of the 1st level. Material and methods. For the period from 2017 to 2020. 508 injured with road polytrauma were admitted to the hospital. Of these, trauma and secondary injuries were diagnosed in 108 people (21.3%), which were divided into three groups: the first - 73 (67.6%) victims with the injury of the OMVS, the second - 25 (23.1%) with secondary damage kidney, the third - 10 (9.3%) patients with «neurogenic bladder» with spinal trauma. The assessment of the severity of damage was carried out using the ISS scales and tables of the IH P and IH C. Results. It has been shown that the introduction of an interdisciplinary approach to the organization of in-hospital routing and differentiated algorithms of medical and diagnostic tactics based on the concept oftraumatic disease, led to the establishment of a final diagnosis in every third victim in the early stages, as well as to a decrease in the overall mortality rate by 3.7%, the overall mortality rate was 12,2%. The key directions for improving the efficiency and quality of care in case of dominant and concomitant trauma of the urinary system have been identified, based on the tactics of programmed multistage surgical treatment (Damage Control Urological). Conclusion. In the FSBI «3CVKG A.A. Vishnevsky «developed, organized and implemented a system and algorithm for the provision of specialized medical care for trauma to the Ministry of Railways, including high-tech assistance to victims of road accidents, associated with the regional and federal services of disaster medicine.
Urologiia. 2021;(5):15-25
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The methodology of remote monitoring of patients with urinary stone disease: development and primary approbation

Lebedev G.S., Shaderkin I.A., Gazimiev M.A., Rudenko V.I., Dyakonov I.V., Alfimov A.E., Vladzimirsky A.V., Gazimiev A.M.


Introduction. Urolithiasis is a clinically and socially significant disease that requires long-term follow-up in order to prevent stone recurrence. Currently, telemedicine consultations in the "patient-doctor" format are actively used in urology, however, the methodology, technological base and assessment of the efficiency of remote monitoring of the patient's health status are virtually not developed. Aim. To provide basics for the methodology of remote monitoring of patients with urolithiasis for detailed comprehensive examination and comprehensive metaphylaxis of recurrent stone formation. Materials and methods. A comprehensive clinical examination was carried out on the basis of the Institute of Urology and Human Reproductive Health, the National Medical Research Center on Urology and the Institute of Digital Medicine of FGAOU VO I.M. Sechenov First Moscow State Medical University during the period from 1st February to 1st December 2020. A total of 30 patients with urolithiasis were included in the study. Remote monitoring of health status was carried out using a portable analyzer "ETTA AMP-01" on dipstick. Data transmission was performed through a mobile application, which is part of the "NetHealth" information system ( The values and frequency of urine tests performed by the patient independently, as well as patient satisfaction and adherence to the monitoring technology were evaluated. Analytical, clinical, sociological and statistical research methods were used. Results. By systematizing published data and our own clinical experience, we have developed a model for remote monitoring of the health status of patients with urinary stone disease, which included a system of indications and contraindications, a program and an order of the monitoring, as well as a basic technological solution (medical devices and a hardware-software complex). In this study, median duration of remote monitoring was 168 days. According to the questionnaire, general positive assessment and desire to continue telemonitoring was seen in 100.0% of cases, while 86.7% of patients positively evaluated the technical accessibility and reliability of the system and 93.3% considered the quality and availability of medical care as high. Conclusion. A methodology for remote monitoring of patients with urolithiasis has been developed with the aim of preventing recurrent stone formation. There was a high adherence of patients to remote monitoring with a tendency to decrease in values after 4 and 6 months. During these periods, it is necessary to carry out routine consultations by the physician who appointed remote monitoring in order to continue the follow-up program. There was a high satisfaction of patients with remote monitoring, and they pointed out the quality and availability of urological care owing to telemedicine technologies.
Urologiia. 2021;(5):26-34
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Neurogenic overactive bladder: focus on cognitive function

Korshunova E.S., Korshunov M.N., Nuzhnyi E.P., Zakroyshchikova I.V., Zabirova A.K., Korshunov D.M., Suponeva N.A., Darenkov S.P.


Background. An overactive bladder and cognitive impairment are two medical and social problems, which have an outmost importance, affecting the quality of life. Both disorders are common in the practice of a urologist, neurologist, internist, and other physicians. Parkinson’s disease and multiple sclerosis are the most common neurological diseases, which often manifest by pelvic dysfunction and cognitive dysfunction. The clinician needs to understand the pathogenesis of the underlying disease and the pharmacologic properties of drugs, which can be used both in neurology and urology, as well as in other related specialties. Aim. To evaluate cognitive functions in patients with neurogenic overactive bladder treated with trospium chloride. Materials and methods. A total of 45 patients with neurological disease (28 with Parkinson’s disease [group 1] and 17 with multiple sclerosis [group 2]) were included in the study. All patients had symptoms of an overactive bladder. Trospium chloride was administered in an individually adjusted dose for 12 weeks. Cognitive functions were assessed using the international Montreal Cognitive Assessment (MoCA) before and after the therapy. A change of total scores over time was assessed using the paired Wilcoxon test. The level of significance of <0.05 was used (confidence level of 95%). Results. A significant decrease in all studied parameters of an overactive bladder in both groups was seen. The baseline evaluation of the total score on the MoCA scale prior to the start of taking trospium chloride revealed the presence of moderate cognitive impairment (21.3±2.9 points) in patients of the group 1. After 12 weeks of therapy, no significant change in cognitive functions was observed (21.7±3.1 points; p>0.05). In group 2, moderate cognitive impairment (MoCA 22.5±3.7 points) was found at baseline. After taking trospium chloride, no significant changes were noted (MoCA 22.9±4.1 points) (p> 0.05). No central nervous system side effects were reported in any group. Conclusion. Trospium chloride is an effective drug, which does not affect cognitive functions in patients with neurogenic overactive bladder. This drug is safe to use in both Parkinson’s disease and multiple sclerosis, considering the low risk of cognitive impairment in polypharmacy.
Urologiia. 2021;(5):35-40
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Study of the structure and microflora of urethral tissues in urethral pain syndrome

Streltsova O.S., Boldyreva M.N., Kiseleva E.B., Molvi M.A., Lazukin V.F.


Urethral pain syndrome (UPS) is characterized by the occurrence of persistent or recurrent pain in the urethra in the absence of a confirmed infection and other obvious local pathological changes. The study of its pathogenetic aspects is important first of all for understanding the causes of the disease, to prescribe effective treatment, specific recommendations for the prevention and treatment of this disease are also absent. This paper presents the advanced experience of our research group on the study of the urethral state by the in vivo cross-polarization optical coherence tomography (CP OCT) method, and also the results of the microbiota analysis in the urethral tissues. The purpose of the study is to search for the risk factors for UPS and the character of changes in the urethral tissues, using the data of: 1) concomitant pathology, 2) structural changes in the urethral wall in UPS in comparison with chronic cystitis of bacterial etiology 3) studying the microbiota of urethral tissues. Materials and methods: The condition of the urethra was studied in 109 patients: 55 of them with UPS (group «OTS»), without clinical manifestations of inflammation; 41 - with chronic inflammation of the lower urinary tract of various origins (group «Inf»); in 14 patients with stones of the upper urinary tract without pyelonephritis, the urethra was taken as the norm (group «N»). All performed a clinical minimum of studies, also cystoscopy with the study of the bladder triangle, the neck of the bladder and the urethra by the method of in vivo tissue imaging - CP OCT. The device «OCT-1300U» with wavelength of 1300 nm is used. To determine the possible role of UPS disease background, the analysis of concomitant pathology preceding the development of UPS was performed. To analyze the relationship of changes in the urethral tissues with the composition of its microbiota, a PCR study of biopsies from the proximal segment of the urethra was performed in 13 patients with UPS. Results: Qualitative comparison of the thickness and character of the OCT signal of the urethral wall layers observed using CP OCT in the studied groups of patients allowed us to establish that the state of the epithelium and connective tissue structures of the mucous membrane in patients with UPS is not the norm, changes are similar to those in chronic inflammation. Changes in the character of the OCT signal were recorded in all parts of the urethra, but in the middle third they are most pronounced and most critical. In UPS, there is a brightly pronounced reorganization of the connective tissue stroma components. Pronounced fibrosis of subepithelial structures (increased signal brightness in the cross-channel compared to the norm) with their thickening was recorded in 48.2% of cases, and thinning/lack of visualization of the epithelial layer was detected in 20.5%, and in chronic inflammation 55.5% and 40.6% of cases, respectively. According to the results of PCR, only one patient had significant total bacterial contamination of the biopsy (ТВС=1047). In all other cases, the total bacterial mass of the biopsies was at the level of negative control. Conclusions. In patients with UPS, the presence of several concomitant, often chronic, diseases was revealed, which may be a premorbid background and one of the risk factors for the occurrence and maintenance of UPS. Pilot PCR studies of biopsies from the proximal segment of the urethra indicate that low values of bacterial contamination in the majority of patients with UPS do not exclude the possible role of bacteria in the development of the disease in some patients. The CP OCT method used in this study is currently the only one in vivo method of visualization of the urethral mucosa, which provides real-time images of structural changes in the epithelial (atrophy or hyperplasia) and connective tissue (active or latent inflammation with cellular infiltration or fibrosis) layers of the urethra, allowing better understanding of the pathogenesis of the disease and monitoring of therapy.
Urologiia. 2021;(5):41-49
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The use of ultrasound imaging in minimally invasive percutaneous nephrolithotomy. Can we completely abandon fluoroscopy?

Kutluev M.M., Safiullin R.I.


Aim. To determine the possibility of performing minimally invasive percutaneous nephrolithotomy (PCNL) under ultrasound guidance with the use of X-ray during the access tract formation. Materials and methods. The results of 102 mini-PСNL procedures, performed by a single surgeon during the period 2018-2019, were analyzed retrospectively. In the beginning, ureteral catheter Ch5 was put into an ipsilateral ureter. Further, a puncture of the collecting system was performed with an advancement of the guidewire. At the next stage, a dilation of tract was done using X-ray guidance for the safe formation of the working channel, followed by holmium lithotripsy. At the end a nephrostomy or JJ-stent was left. Results. The mean age of the patients was 53.13+12.9, while average BMI was 29.3+6.5. In total, there were 44.1% of women. The average stone size was 20.7+10.9 mm; 45.1% of stones were left-sided. Staghorn stones accounted for 15.7% of cases and hydronephrosis was found in 18.6% of patients. The time for creating renal access, dilation of the nephrostomy tract, total operative time and fluoroscopy time were: 19.6+13.1, 7.7+4.2, 107.7+49.9, 57.1+41.2 minutes, respectively. In the Group I there were 32 (31.4%) patients undergoing to PCNL under X-ray guidance, while in Group II (n=70, 68.6%) combined US+X-ray control was used. The patients age (52.2+12.6 vs 53.6+13.2, p<0.05) and the stone size (20.6+8.9 vs 20.7+10.4, p=0.30) were comparable in both groups. There were slightly shorter access time and the total operative time in group II compared with group I (20.6+12.3 vs 19.2+13.5, p=0.27; 108.1+43.3 vs 106.9+53.2, p=0.25 respectively). In total, hematocrit level decreased by 4.5% and blood transfusions was done in 3 patients. Postoperative complications developed in 9 cases in both groups (according to the Clavien-Dindo classification, all complications were grade I-II). The stone-free rate (SFR) was 87.2%, and a second-stage was required in 2 cases. Discussion. The use of ultrasound guidance improves visualization of the collecting system and contributes to the creation of an optimal renal access. It significantly reduces the radiation exposure to the patient and the operating team. We were able to puncture the collecting system in all cases. SFR after PCNL under ultrasound guidance was 88.6%, which is comparable to the results of conventional PCNL with X-ray navigation. Conclusion. PCNL can be performed effectively and safely under ultrasound guidance, which reduces the number of renal punctures and lowers the complication rate. However, this technique also has disadvantages, including longer puncture time in morbidly obese patients without hydronephrosis. With growing experience, the number of unsuccessful kidney punctures decreases, as well as operative time. The use of fluoroscopy during dilatation of the nephrostomy tract allows for preventing additional injuries of the collecting system.
Urologiia. 2021;(5):50-54
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Morphofunctional characterization and DNA stability of spermatozoa in primary examination of men fertility

Proshin S.N., Bairamov A.A., Zelener A.O., Radjabov R.M., Komyakov B.K.


Aim. To assess the morphological and functional characteristics of spermatozoa and DNA stability in patients with normal seed parameters and with an ITZ exceeding the threshold value. Patients and methods. 85 males were studied for semen quality parameters. The morphological anomalies of head, middle piece, and tail of spermatozoa were estimated and presented in illustrations. Due to results elaborated the index of teratozoospermia was calculated. Then the Comet assay was performed. Results. It has been found that spermatozoa from patients with high teratozoospermia index possessed decreased motility as compared to ones from patients with low index of teratozoospermia. It was not found any difference in concentration of spermatozoa between groups of males which possess low and high index ofteratozoospermia. The spontaneous frequency of DNA damage estimated by means of single cell gel electrophoresis followed by silver staining in spermatozoa from healthy donors did not exceed 3,1±0,6. The frequency of DNA damages in sperm of patients with abnormal index of teratozoospermia exceeded 39,6±7,4% (p<0,01). Conclusions. Our results suggest that minor morphological changes in spermatozoa do not affect their motility, while significant morphological abnormalities with ITZ exceeding threshold values are closely associated with impaired DNA stability and dramatically reduce the quality of patient’s seed. Summary. In the initial assessment of patient fertility the attention should be focused on a comprehensive study of sperm DNA morphology and stability.
Urologiia. 2021;(5):55-58
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Experimental study on the efficiency of rectal suppositories with oxidized dextran in patients with benign prostatic hyperplasia

Novikova E.G., Troitsky A.V., Ukah H.U., Selyatitskaya V.G.


Aim: to evaluate therapeutic activity of oxidized dextran after rectal administration in a modified sulpiride model ofbenign prostatic hyperplasia in mice. Materials and methods: The therapeutic activity of oxidized dextran was studied in an experimental model of benign prostatic hyperplasia in mice (sulpiride model). All in vivo studies were carried out on 30 male BALB/c mice with an average body weight of 30-35 g. Results: It was found that rectal administration of a solution of oxidized dextran effectively neutralizes pathomorphological changes in experimental model of benign prostatic hyperplasia. In the group of animals, which received 2% solution of oxidized dextran as treatment, the most prominent therapeutic effect in an experimental model was seen and it was confirmed by a decrease in the bladder detrusor thickness and the normalization of its lumen.
Urologiia. 2021;(5):59-61
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The impact of energy drinks consumption on male reproductive health

Akaev R.M., Adilov A.S.


Aim: to evaluate the relationship between the use of energy drinks and the decline in male reproductive function. Materials and methods: The analysis ofscientific publications dedicated to the issue was carried out. The results of the study, which involved 60 patients aged 22 to 40 years, are presented. The directions for further scientific search are suggested. Results: According to our study, there is a correlation between energy drinks consumption and decreased ejaculate quality. Conclusion: systematic use of energy drinks has a negative impact on male reproductive function.
Urologiia. 2021;(5):62-64
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Bilateral simultaneous retrograde intrarenal surgery

Popov S.V., Orlov I.N., Suleymanov M.M., Skryabin O.N., Sytnik D.A., Emelyanenko A.V.


Bilateral nephrolithiasis is one of the most prevalent and severe form of urinary stone disease, that is usually linked with endocrinological disorders. These patients are quite often treated in our clinic. A clinical case of patient with bilateral nephrolithiasis who undergone to bilateral simultaneous retrograde intrarenal surgery is presented.
Urologiia. 2021;(5):65-68
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Laparoscopic ONLAY ureteroplasty using buccal mucosa graft for long recurrent stricture of the upper third of the ureter

Volkov A.A., Budnik N.V., Zuban O.N.


Long strictures of the upper third of the ureter are most often recurrent and occur after endourological and reconstructive procedures. The lack of native tissues and an impossibility of substitution by bowel segment in some cases dictates the use of alternative surgical techniques. Our first experience of laparoscopic onlay ureteroplasty using buccal graft for long stricture of the upper third of the ureter is described in the article. The length of the stricture was 6 cm. The operation time was 210 minutes, while blood loss volume was less than 100 ml. The patient did not have any surgical complications. Drains were removed in timely manner. The patient was discharged from the hospital in a satisfactory condition on the 8-th day. The ureteral stent was removed after 4 weeks. Kidney ultrasound was performed on a monthly basis. According to IVU after 4 months, the anastomosis was completely patent. This method can be considered as an alternative to more complex procedures in selected patients.
Urologiia. 2021;(5):69-72
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Predictors of bladder neck contracture after transurethral procedure on the prostate

Abbosov S.A., Sorokin N.I., Kadrev A.V., Shomarufov A.B., Nesterova O.Y., Akilov F.A., Kamalov A.A.


The development and widespread implementation of modern endourological procedures for the treatment of benign prostatic hyperplasia (BPH) has led to a significant reduction in postoperative complications, but these interventions are associated to an increase of bladder neck contracture (BNC) rate. Various data on the frequency, pathogenesis, and risk factors for the development of BNC after endourological interventions are presented in the literature review. The prevalence of BNC after transurethral procedures depending on the type of energy used reaches up to 10%. Risk factors of BNC included the presence of chronic prostatitis and urinary tract infections, as well as small volume BPH. The age, cardiovascular diseases, type 2 diabetes, obesity, and a long-term smoking are considered as additional risk factors. A detailed study of the risk factors for BNC will further minimize BNC rate after transurethral procedures, thus improving the quality of life of patients.
Urologiia. 2021;(5):73-77
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Lower urinary tract symptoms and COVID-19

Bernikov A.N., Kupriyanov A.A., Stroganov R.V., Arefieva O.A., Khodyreva L.A., Zaitsev A.V.


The data presented in the review showed that the coronavirus affects not only the lungs, but also the organs of the urinary system. The new virus causes a mosaic, multi-organ disease with severe consequences after the egg and has a wide organotropism. The role of SARS-CoV-2 in the development of lower urinary tract symptoms (LUTs), which are manifested by frequent, imperative urges, dysuria, nocturia, is not entirely clear. It is assumed that biologically active substances, the activation of which is caused by a virus, play a certain role in the development of SNMP, namely the expression of angiotensin converting enzyme 2 (ACE2), cytokines, activation of tolllike receptor 4 (TLR4), etc. An increase in cytokines that are released into the urine and / or expressed in the bladder and the presence of SNMP in patients with coronavirus infection have been called de novo urinary symptoms or COVID-19 associated cystitis (CAC) in the literature. Urinary symptoms de novo or associated cystitis COVID-19 (CAC) develops against the background of a complete lack of data for the presence of a bacterial pathogen in the urine. Despite the unusual manifestation of coronavirus infection, similar mechanisms of damage to urothelial cells in viral and bacterial infections give us the right to think about the use of pathogenetically justified prevention of the development of an inflammatory reaction in the urinary tract, as well as short-and longterm consequences of this disease. For this purpose, it is necessary to recommend drugs that have a multifactorial effect: diuretic, anti-adhesive, anti-inflammatory and regulate the local immunity of the bladder mucosa. We assume that against this background, we can expect a decrease in the number of complications from the organs of the urinary system, and more successful rehabilitation of patients with coronavirus infection and in the post-ovarian period. Final conclusions and recommendations will be available after well-planned clinical trials have been conducted.
Urologiia. 2021;(5):78-83
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An influence of zinc on male infertility

Osadchuk L.V., Danilenko A.D., Osadchuk A.V.


Trace elements play an important role in human health. They are involved in growth, development, reproduction, and other physiological functions. Among them, special attention is paid to zinc, which is an essential trace element required for the normal functioning of many organ systems. Experimental data have been accumulated indicating a significant role of zinc in the functioning of the male reproductive system and the spermatogenesis. Zinc concentration in seminal plasma is considerably higher compared to those in other body fluids. In contrast to its serum concentration, seminal zinc level is associated with the sperm concentration, motility and morphology. Under dietary deficiency, Zinc supplementation can significantly increase the ejaculate volume, sperm motility and morphology and improves overall sperm quality in infertile patients. Zinc, being a structural element of a large number of different macromolecules and enzymes, shows antioxidant, antibacterial and antiapoptotic properties in the testes. It should be considered as one of the trace elements with great potential for the prevention and treatment of male infertility and subfertility. The aim of this review is to analyze current publications and summarize information about the effect of zinc on male fertility and its properties related to sperm quality and successful fertilization.
Urologiia. 2021;(5):84-93
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A place of silodosin in the treatment of LUTS/BPH according to evidence-based medicine and real clinical practice

Kotov S.V., Bogdanov D.A.


Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) are common disorder in older men. The mainstay of conservative treatment for BPH is a1-adrenoblockers. A review of the literature on silodosin, a selective α-adrenergic blocker, is discussed in the article. In clinical studies, there was a significant improvement in IPSS scores and maximum urinary flow rate in patients who received silodosin at a daily dose of 8 mg compared to those receiving placebo. It should be noted that silodosin has demonstrated long-term safety and early onset of efficacy. Compelling literature data to support the clinical benefit of silodosin for the treatment of LUTS associated with BPH is presented.
Urologiia. 2021;(5):94-98
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Super-selective prostatic artery embolization as minimally invasive surgical treatment in patients with BPH

Karpov V.K., Sharapov B.M., Kapranov S.A., Zlatovratskiy A.G., Kamalov A.A.


Benign prostatic hyperplasia (BPH) is a widespread socially significant disease. Minimally invasive surgical treatments can reduce the surgical and anesthetic risk. One of the most effective methods of minimally invasive surgical treatment of BPH is superselective prostatic artery embolization (prostatic artery embolization; PAE). PAE is a method with proven effectiveness and has been included in the clinical recommendations of the Ministry of health of the Russian Federation for the treatment of BPH since 2019.
Urologiia. 2021;(5):100-104
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Ultrasound-based techniques of targeted prostate biopsy

Chernysheva D.Y., Popov S.V., Orlov I.N., Malevich S.M., Neradovskiy V.A.


The article is devoted to the multiparametric ultrasound techniques for prostate biopsy targeting. This literature review illustrates the variety of ultrasound-based targeting procedures and presents data concerning the diagnostic value of each. A special attention is given to every targeted technique limitations and the opportunity for the MTI-fusion.
Urologiia. 2021;(5):105-110
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Current approaches to targeted prostate biopsy

Popov S.V., Orlov I.N., Malevich S.M., Sushina I.V., Grin' E.A., Topuzov T.M., Vjazovcev P.V., Chernysheva D.Y., Neradovskiy V.A.


Currently, prostate cancer (PCa) is the second most common malignancy in men after lung cancer and the fifth leading cause of death worldwide. According to world and national statistics, over the past 20 years, there has been a steady increase in both incidence and mortality from PCa. Prostate biopsy is the cornerstone of the PCa diagnosis. However, recently, systematic transrectal biopsy as a standard approach has been questioned, since it has significant drawbacks that reduce the quality of PCa diagnosis. Considering the clinical importance of accurate PCa staging, MRI-guided targeted biopsy has been developed, which is currently the most accurate technique for taking a sample of tissue from suspicious areas. The optimal approaches to targeted prostate biopsy and the potential possibilities of including multiparametric MRI in the primary diagnostic algorithm are highlighted in this review, based on the results of large studies. The method allows to increase the overall PCa detection rate, the detection rates of clinically significant PCa, reduce the frequency of diagnosis of low-risk tumors and increase the overall accuracy of PCa detection, which has an outmost importance for the patient selection for active surveillance and to control disease progression.
Urologiia. 2021;(5):112-117
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Professor Joachim Albarran. Urologist and scientist ahead of his time

Morgoshiia T.S., Kalashnikova V.D.


The articIe anaIyzes the scientific and practicaI activities of the prominent French urologist Professor Joachim Albarran (1860-1912). It is noted that a student of the founder of French uroIogy F. Guyon I. Albarran in 1906 was elected in his place Professor of urology and head of the Department of the Necker hospitaI (HopitaI Necker) in Paris. It is shown that in 1891 he published a work on bladder tumors, creating a new progressive classification of them. This paper presents well-known monographs by I. Albarran on the mechanism of origin ofhydronephrosis, tubercuIosis, and kidney tumors. He deveIoped a method for studying the functionaI activity of the kidneys and proposed the method of «experimental polyuria» (1905). It is also noted that I. Albarran invented the catheterization cystoscope and this made ureteraI catheterization a method widely available in practical surgery. I. Albarran’s extensive operational experience was described in his manual of operative surgery of the urinary tract (1909), which stiII has not Iost its vaIue. I. AIbarran created a briIIiant scientific schooI, from which came a whoIe gaIaxy of outstanding cIinicians and uroIogists.
Urologiia. 2021;(5):118-120
pages 118-120 views

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