IS THERE SCREENING FOR URINARY TUBERCULOSIS?


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Abstract

Introduction. Most of the patients with genitourinary tuberculosis are detected too late. One of the reasons for this is the lack of a simple, cheap, reliable screening. The purpose of this study was to investigate the possibility of using a recombinant tuberculosis allergen (diaskintest) as a screening test to detect patients with genitourinary tuberculosis. Material and methods. This is a simple prospective, open-label cohort study comprising 197 patients admitted to the Novosibirsk Research Institute of Tuberculosis for differential diagnosis in 2014-2016. Of then, 72 patients were found to have urogenital tuberculosis, while 125 patients had chronic nonspecific infections. Results. The sensitivity of the Koch’s subcutaneous tuberculin test and the diaskintest was 80.4% and 63.8%, respectively. The specificity of the Koch’s test was 91.5%, which makes it still possible to consider it essential in the differential diagnosis of urogenital tuberculosis and nonspecific urogenital infections. A high percentage of positive diaskintest results in patients with chronic infectious and inflammatory diseases of the genitourinary system caused a low specificity of the test - 37.5%. Conclusion. Diaskintest can be used in screening for genitourinary tuberculosis, but its positive result indicative for diagnosis. It may be used only as a reason for in-depth phthisiourological examination using additional provocative tests, in particular, Koch’s test, which showed high diagnostic performance.

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About the authors

S. Yu. Shevchenko

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia; Novosibirsk State Medical University of Minzdrav of Russia

Email: Shevchenko_S@list.ru
Junior Researcher

E. V. Kulchavenya

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia; Novosibirsk State Medical University of Minzdrav of Russia

Email: urotub@yandex.ru
Dr.Med.Sci., Prof., Principal Researcher at the Department of Urology

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