BIOMARKERS OF RENAL INJURY IN CONTACT URETERAL LITHOTRIPSY


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Abstract

Aim. To optimize the transurethral endoscopic management of patients with ureterolithiasis by measuring biomarkers of renal parenchymal damage. Materials and methods. One hundred fifty-one patients with solitary ureteral stones were tested for levels of cystatin C, neutrophil gelatinase-associated lipocalin, β2-microglobulin and interleukin 18. Results. An increase in the levels of markers of renal injury was observed both in the preoperative period and after CULT. Differences in the values of these indices depended on the timing of the CULT, the size and location of the stone and the type of lithotripter. Conclusions. All patients were found to have damage to the renal tubular system. The established critical values of the markers of renal injury in ureterolithiasis may be used as diagnostic criteria for renal injury.

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About the authors

A. I Tarasenko

Ministry of Healthcare of the Russian Federation

Ph.D., Deputy Director of Department of Medical Education and Personnel Policy Moscow, Russia

A. M Pushkarev

Bashkir State Medical University of Minzdrav of Russia

Dr.Med.Sci., Prof. at the Department of Urology with the course of IPE

I. G Rakipov

G.G. Kuvatov Republican Clinical Hospital

Ph.D., Urologist

A. V Alekseev

Bashkir State Medical University of Minzdrav of Russia

Ph.D., Associate Prof. at the Department of Urology with the course of IPE

Ya. V Kondratenko

G.G. Kuvatov Republican Clinical Hospital

Ph.D., Urologist

V. N Pavlov

Bashkir State Medical University of Minzdrav of Russia

Corr.-member of the RAS, Dr.Med.Sci., Professor, Head of the Department of Urology with the Course of PE

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