THE ROLE OF STRESS-INDUCED CHRONIC SUBCLINICAL INFLAMMATION IN THE PATHOGENESIS OF THE CHRONIC PELVIC PAIN SYNDROME IIIB IN MEN


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Resumo

This literature review of recent clinical and experimental studies describes the role of oxidative stress in the multifactorial and interdisciplinary pathogenesis of non-inflammatory chronic pelvic pain syndrome IIIB (CPPS-IIIB) in men. The authors outline general biological nature of oxidative stress and its mechanisms. More detailed information is presented on cytokine-mediated chronic subclinical inflammation, one of the key mechanisms of oxidative stress, which is currently being actively studied. It is shown that the imbalance between pro- and anti-inflammatory cytokines observed in patients with CPPS-IIIB can explain some features of the clinical course (in particular, the characteristics of the pain syndrome) and the progression of this disease. In this regard, cytokine profiling of prostatic secretion can provide valuable diagnostic, prognostic and monitoring information in the management of this category of patients. Recently published evidence has demonstrated the essential role of the cytokine-mediated chronic inflammatory response as a mechanism of oxidative stress in the pathogenesis of CPPS-IIIB. Further studies in this area are warranted and in the long term may become a basis for the development of new effective pathogenetic pharmacotherapy of CPPS-IIIB.

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Sobre autores

I. Shormanov

YSMU of the Ministry of Health of the Russian Federation

Email: kafuro@mail.ru
Dr.Med.Sci., Prof., Head of the Department of Urology with Nephrology Yaroslavl, Russia

I. Mozhaev

YSMU of the Ministry of Health of the Russian Federation

Email: kafuro@mail.ru
Senior Laboratory Assistant at the Department of Urology with Nephrology Yaroslavl, Russia

Kh. Sokolova

YSMU of the Ministry of Health of the Russian Federation

Email: manoylov@yandex.ru
Ph.D., Associate Professor at the Department of Urology with Nephrology Yaroslavl, Russia

A. Solov’ev

YSMU of the Ministry of Health of the Russian Federation

Email: kafuro@mail.ru
Teaching Assistant at the Department of Urology with Nephrology Yaroslavl, Russia

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