Clinical significance of PET/CT molecular cell diagnostics of inflammatory diseases of the urinary system
- Authors: Berdichevsky B.A.1, Berdichevsky V.B.1, Sapozhenkova E.V.1, Pavlova I.V.2, Gonyaev A.R.3, Boldyrev A.L.4, Shidin V.A.1, Averina N.V.5, Simonov A.V.6, Korabelnikov M.A.6
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Affiliations:
- FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia
- Medical Sanitary Department «Neftyanik»
- Clinical Hospital «Mother and Child»
- GBUZ TO Regional clinical hospital No2
- GAUZ TO MC «Medical City»
- GAUZ TO MC "Medical City"
- Issue: No 5 (2023)
- Pages: 22-27
- Section: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/625310
- DOI: https://doi.org/10.18565/urology.2023.5.22-27
- ID: 625310
Cite item
Abstract
Introduction. The formation of a local pathological process is associated with a disturbance of functional molecular bonds both inside the cell and in the intercellular space surrounding it. It precedes the appearance of laboratory and clinical manifestations of the disease and is available for non-invasive analysis only by PET/CT scanning.
Aim. To determine the clinical significance of PET/CT scanning in molecular cell diagnosis of inflammatory diseases of the urinary system.
Materials and methods. A comparative study of the results of whole-body PET/CT with 11C-choline and 18F-FDG glucose was carried out with a comparison with the results of kidney and bladder morphobiopsy in 96 urological patients, including 56 women and 40 men with a median age of 51.5 (37; 61). They were randomized into three equal groups: without clinical and laboratory manifestation of urological diseases, with isolated urinary syndrome and clinical and laboratory manifestation of pathology.
Results. A synchronous decrease in the metabolism of 11C-choline and 18F-FDG glucose in the kidney parenchyma and a significant increase in the bladder wall were revealed, which correlated with the severity of clinical and laboratory manifestations.
Conclusion. PET/CT technology for studying lipid and carbohydrate metabolism in the organs of the urinary system can be recommended as an additional method for diagnosing urological disorders at the early molecular-cellular stages and during navigation during targeted biopsy.
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About the authors
B.A. A. Berdichevsky
FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia
Author for correspondence.
Email: doktor_bba@mail.ru
ORCID iD: 0000-0002-9414-8510
SPIN-code: 4630-3855
Ph.D., MD, professor at the Department of Oncology with a course of Urology
Russian Federation, TyumenV. B. Berdichevsky
FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia
Email: urotgmu@mail.ru
ORCID iD: 0000-0002-0186-6514
SPIN-code: 9768-5704
Ph.D., MD, professor at the Department of Oncology with a course of Urology
Russian Federation, TyumenE. V. Sapozhenkova
FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia
Email: ekaterina_chibulaeva@mail.ru
ORCID iD: 0000-0003-2253-2297
SPIN-code: 7270-2232
Ph.D., associate professor at the Department of Normal Physiology
Russian Federation, TyumenI. V. Pavlova
Medical Sanitary Department «Neftyanik»
Email: iraena@mail.ru
Ph.D., urologist, assistant at the Department of
Oncology with a course of Urology
A. R. Gonyaev
Clinical Hospital «Mother and Child»
Email: a.gonyaev25@yandex.ru
ORCID iD: 0000-0002-1619-4714
urologist
Russian Federation, TyumenA. L. Boldyrev
GBUZ TO Regional clinical hospital No2
Email: boldyrev.a.l@yandex.ru
urologist
Russian Federation, TyumenV. A. Shidin
FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia
Email: vshidin@mail.ru
Ph.D., MD, associate professor of the Department of Histology and Embriology
Russian Federation, TyumenN. V. Averina
GAUZ TO MC «Medical City»
Email: medgorod@med-to.ru
Head of the Radiological Center
Russian Federation, TyumenA. V. Simonov
GAUZ TO MC "Medical City"
Email: ward72@mail.ru
Head of the Department of Oncopathology of Pathological and anatomical bureau
Russian Federation, TyumenM. A. Korabelnikov
GAUZ TO MC "Medical City"
Email: kma_doc@mail.ru
ORCID iD: 0000-0003-2553-0545
radiologist at the Radiological Center
Russian Federation, TyumenReferences
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