Development of purulent-destructive forms of acute pyelonephritis in patients with a history of new coronavirus infection COVID-19
- Authors: Pulbere S.А.1,2, Kotov S.V.1,2, Magomedov М.А.1,2, Zheltikova Е.А.1,2
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Affiliations:
- Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of Russia
- GKB №1 named after N.I. Pirogov of Moscow Healthcare Department
- Issue: No 6 (2023)
- Pages: 44-50
- Section: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/626009
- DOI: https://doi.org/10.18565/urology.2023.6.44-50
- ID: 626009
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Open Access
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Abstract
Introduction. Since 2019, more than 600 million cases of the new coronavirus infection COVID-19 have been reported worldwide. According to various studies, the development of a systemic inflammatory response and «cytokine storm» play an important role in the pathogenesis of kidney damage, which leads to impaired microcirculation, increased thrombus formation and the development of ischemic areas in the parenchyma.
Aim. To study the frequency and possible causes of purulent forms of pyelonephritis in patients who have had a new coronavirus infection COVID-19.
Materials and methods. The prospective and retrospective study included the results of 403 patients with acute non-obstructive pyelonephritis in the pre-COVID period and those with a history of a new coronavirus infection.
Results. In patients with acute non-obstructive pyelonephritis without past urological history who had a new coronavirus infection, an increase in purulent-destructive forms from 5.0 to 17.0% was noted. One of the reasons is increased antibiotic resistance and the emergence of pan-resistant uropathogens due to irrational use of antibacterial drugs.
Conclusion. The use of reserve antibacterial drugs in patients with acute pyelonephritis as empirical therapy and anticoagulants in order to improve microcirculation and prevent thrombosis is pathogenetically justified.
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About the authors
S. А. Pulbere
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of Russia; GKB №1 named after N.I. Pirogov of Moscow Healthcare Department
Author for correspondence.
Email: pulpiv@mail.ru
Ph.D., MD, professor at the Department of Urology and Andrology
Russian Federation, Moscow; MoscowS. V. Kotov
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of Russia; GKB №1 named after N.I. Pirogov of Moscow Healthcare Department
Email: urokotov@mail.ru
Ph.D., MD, professor, Head of the Department of Urology and Andrology
Russian Federation, Moscow; MoscowМ. А. Magomedov
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of Russia; GKB №1 named after N.I. Pirogov of Moscow Healthcare Department
Email: mma16@bk.ru
Ph.D., associate professor at the Department of Anesthesiology and Intensive Care
Russian Federation, Moscow; MoscowЕ. А. Zheltikova
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of Russia; GKB №1 named after N.I. Pirogov of Moscow Healthcare Department
Email: doctorzheea@gmail.com
Ph.D. student at the Department of Urology and Andrology
Russian Federation, Moscow; MoscowReferences
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