Use of a combined form of prostate extract and alpha-adrenoblocker in patients after transurethral resection of the prostate
- 作者: Pavlov V.N.1, Kazikhinurov A.A.1, Sabirzyanov S.S.1, Kazikhinurov R.A.1, Karaguzin R.A.1
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隶属关系:
- Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
- 期: 编号 2 (2025)
- 页面: 29-34
- 栏目: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/683338
- DOI: https://doi.org/10.18565/urology.2025.2.29-34
- ID: 683338
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Introduction. Prostate extract has pronounced anti-inflammatory and anti-androgenic properties, which contribute to a reduction in the volume of the prostate and an improvement in urination. Alpha-adrenoblockers, in turn, exert a relaxing effect on the smooth muscles of the bladder and prostate, thereby facilitating the urination. The combined use of these two drugs may provide a synergistic effect, leading to a pronounced improvement in quality of urination and accelerates recovery in patients after transurethral resection of the prostate. This approach may be more effective than using only one of these drugs.
Aim. To investigate the efficiency and safety profile of the prostate extract in combination with tamsulosin in patients after transurethral bipolar resection of the prostate.
Materials and methods. A total of 147 patients with benign prostatic hyperplasia (BPH) of stage II without severe concomitant diseases were included in the clinical study. The age of the men ranged from 48 to 81 years (61.7±1.4). All patients underwent transurethral bipolar resection of the prostate. Patients were randomized into two groups. In the main group, men received from the first postoperative day a combination of prostate extract with an alpha-adrenoblocker (prostate extract in powder 50 mg in terms of water-soluble peptides 10 mg and tamsulosin hydrochloride 0.4 mg) in the form of suppository after spontaneous bowel evacuation or enema daily for 30 days (n=70). In the control group, only alpha-adrenoblocker (tamsulosin 0.4 mg once a day for 30 days) in the postoperative period was given (n=77).
Results. In the main group, there was a reduction in the mean total IPSS score by 34.5% (p <0.05), and improvement in quality of life by 52% (p <0.05). The maximum urine flow rate increased by 69% (p <0.05), and the average urine flow rate increased by 94.6% (p<0.05). The positive effect on erectile function was 17.8% (p <0.05).
Conclusions. Our data allow to recommend this drug in the combined treatment of patients with benign prostatic hyperplasia (BPH) after transurethral resection of the prostate to restore urination function and improve quality of life.
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作者简介
Valentin Pavlov
Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
Email: pavlov@bashgmu.ru
ORCID iD: 0000-0003-2125-4897
rector, Academician of the RAS, Ph.D., MD, professor, Head of the Department of Urology and oncology
俄罗斯联邦, 450008, Republic of Bashkortostan, Ufa, Zaiki Validi Street, 47
Albert Kazikhinurov
Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
编辑信件的主要联系方式.
Email: alberturo@mail.ru
ORCID iD: 0000-0001-9284-7855
Ph.D., MD, professor of the Department of Urology and oncology
俄罗斯联邦, 450008, Republic of Bashkortostan, Ufa, Zaiki Validi Street, 47Sabir Sabirzyanov
Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
Email: sobir08-97@mail.ru
ORCID iD: 0000-0003-4044-0396
urologist
俄罗斯联邦, 450008, Republic of Bashkortostan, Ufa, Zaiki Validi Street, 47
Rustem Kazikhinurov
Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
Email: royuro@mail.ru
ORCID iD: 0000-0001-6813-8549
Ph.D., MD, associate professor of the Department of Urology and oncology
俄罗斯联邦, 450008, Republic of Bashkortostan, Ufa, Zaiki Validi Street, 47Rail Karaguzin
Department of Urology and Oncology, Bashkir State Medical University of the Ministry of Health of Russia
Email: railkaraggguzin@mail.ru
ORCID iD: 0009-0009-8034-3700
6-th year student
俄罗斯联邦, 450008, Republic of Bashkortostan, Ufa, Zaiki Validi Street, 47参考
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